Abstract The Cytochrome P450 (CYP450) family of enzymes is involved in the oxidative
metabolism of many therapeutic drugs, carcinogens and various endogenous substrates …

Introduction: Africa harbors a disproportionate burden of disease when taking into account
the triple challenge caused by HIV/AIDS, tuberculosis (TB) and malaria, against a backdrop …

T hough the pharmacogenetics of drug metabolism had its origins in the 1960s, it is only
during the past 10 years that it began to have clinical impact and pharmaceutical industry …

Genetic diversity is greater in Africa than in other continental populations. Genetic variability
in genes encoding drug metabolizing enzymes may contribute to the high numbers of …

Pharmacogenetics is the study of how interindividual variations in the DNA sequence of
specific genes affect drug response. This article highlights current pharmacogenetic …

Countries in Africa have a high burden of communicable disease, and are experiencing an
increase in noncommunicable diseases due to the effects of globalization, industrialization …

The cytochromes P450 are a family of heme-containing proteins with a major role in the
oxidation of both xenobiotics (including prescribed drugs) and endogenous compounds …

Members of the human cytochrome P450 (CYP) superfamily play a role in the metabolism of
many drugs and several of them, CYP2D6, CYP2C9 and CYP2C19, have been shown to be …

The cytochromes P450 comprise a family of enzymes that are responsible for around three-
quarters of all drug metabolism reactions that occur in human populations. Many isoforms of …

Genetic variation in drug metabolizing enzymes is an important contributor to interindividual
variation in drug disposition and response and is associated with significant clinical …