CK2 and AKT display a high degree of cross-regulation of their respective functions, both
directly, through physical interaction and phosphorylation, and indirectly, through an intense …

Protein kinase CK2 is a highly conserved serine/threonine kinase ubiquitously distributed in
all investigated eukaryotes and involved in several intracellular pathways which control …

CK2 is probably the most pleiotropic Ser/Thr protein kinase with hundreds of endogenous
substrates already known, which are implicated in a variety of cellular functions. At variance …

At variance with most oncogenic protein kinases whose malignancy is generally due to
genetic alterations conferring constitutive activity, CK2 is a highly pleiotropic Ser/Thr protein …

More than a decade after their discovery, the three AKT kinase family members have
emerged as central players in the signaling cascades that regulate cell growth, proliferation …

Disturbance of protein kinase activity may result in dramatic consequences that often lead to
cancer development and progression. In tumors of blood origin, both tyrosine kinases and …

Protein kinase CK2, a protein serine/threonine kinase, plays a global role in activities related
to cell growth, cell death, and cell survival. CK2 has a large number of potential substrates …

Protein kinase CK2 represents a small family of protein serine/threonine kinases implicated
in a variety of biological processes including events relating to cell proliferation and survival …

The protein kinase B (Akt) exemplifies an important switch of cell death and survival within
the PI3K/Akt signaling pathway, which renders Akt a valuable target in diseases such as …

The serine/threonine kinase Akt/PKB pathway presents an exciting new target for molecular
therapeutics, as it functions as a cardinal nodal point for transducing extracellular (growth …