Importance The lack of robust neuroanatomical markers of psychosis risk has been
traditionally attributed to heterogeneity. A complementary hypothesis is that variation in …

Abstract Individuals at Clinical High Risk for Psychosis (CHR-P) demonstrate heterogeneity
in clinical profiles and outcome features. However, the extent of neuroanatomical …

Background Early psychosis in first-episode psychosis (FEP) and clinical high-risk (CHR)
individuals has been associated with alterations in mean regional measures of brain …

Psychopathology is rooted in neurodevelopment. However, clinical and biological
heterogeneity, together with a focus on case-control approaches, have made it difficult to link …

Importance Between-individual variability in brain structure is determined by gene-
environment interactions, possibly reflecting differential sensitivity to environmental and …

Importance The ENIGMA clinical high risk (CHR) for psychosis initiative, the largest pooled
neuroimaging sample of individuals at CHR to date, aims to discover robust neurobiological …

BACKGROUND: Individual structural imaging studies in the pre-psychotic phases deliver
contrasting findings and are unable to definitively characterize the neuroanatomical …

Background Structural magnetic resonance imaging studies in individuals at clinical high
risk (CHR) for psychosis have yielded conflicting results. Methods The aims of this study …

Objectives: Although neuroanatomical abnormalities in subjects at clinical high risk for
psychosis have been considered a putative biomarker of psychosis, relevance of cortical …

Background Cognitive and structural brain abnormalities range from mild to severe in
psychosis. The relationships of specific cognitive functions to specific brain structures across …