It is now exactly 100 years ago (1908) that Paul Ehrlich, who is regarded as the inventor of
the concept of targeted therapy, received the Nobel Prize for Medicine. His initial perception …

Targeted therapies can be defined as drugs developed against a specific target based on its
important biological function in cancer. In contrast, nontargeted therapies are drugs …

The last decades were characterized by enormous technological advances resulting in a
better understanding of disease pathologies and improvement of treatment strategies. The …

Cancer is a genetic disease arising from somatic mutations in cells that confer a survival
advantage and invasive properties characteristic of the malignant phenotype [1]. The …

This volume provides readers a comprehensive and state-of-the-art overview about the
range of applications of targeted therapies for solid tumors. The sections of the book have …

Over the past 30 years, innovative laboratory research has led to an enormous expansion in
our understanding of cellular biology and genetics. Using this knowledge, we have learnt …

The rapidly advancing elucidation of molecular targets in human cancers during the last
decade has provided an excellent basis for the development of novel therapeutics. A huge …

There are currently more than 100 agents officially approved for the treatment of cancer
world-wide. However, the most common epithelial cancers, which cause greater than 75% of …

With the beginning of the 21st century, a new and exciting era for cancer therapy has begun
with the appearance of molecular targeted drugs. Numerous drugs for chemotherapy have …

The tremendous advances achieved in the understanding of cancer biology have delivered
unprecedented progress in molecularly targeted cancer therapy in the past decade. The fast …