Allopurinol hypersensitivity: a systematic review of all published cases, 1950–2012

SN Ramasamy, CS Korb-Wells, DRW Kannangara… - Drug safety, 2013 - Springer
Background Allopurinol is the primary therapy for the management of chronic gout.
Utilization of allopurinol has increased in tandem with the growing prevalence of gout …

Starting dose is a risk factor for allopurinol hypersensitivity syndrome: a proposed safe starting dose of allopurinol

LK Stamp, WJ Taylor, PB Jones… - Arthritis & …, 2012 - Wiley Online Library
Objective Allopurinol is the most commonly used urate‐lowering therapy in gout. Allopurinol
hypersensitivity syndrome (AHS) is a rare but potentially fatal adverse event. Dosing …

Allopurinol hypersensitivity: Pathogenesis and prevention

LK Stamp, PT Chapman - Best practice & research Clinical rheumatology, 2020 - Elsevier
Allopurinol, a first line urate-lowering therapy, has been associated with serious cutaneous
reactions that have a high mortality. A number of risk factors for these serious adverse …

How to prevent allopurinol hypersensitivity reactions?

LK Stamp, ML Barclay - Rheumatology, 2018 - academic.oup.com
Allopurinol hypersensitivity syndrome (AHS) is a severe and sometimes life-threatening
adverse drug reaction. Although AHS is rare, the number of patients with gout requiring …

Allopurinol hypersensitivity: investigating the cause and minimizing the risk

LK Stamp, RO Day, J Yun - Nature Reviews Rheumatology, 2016 - nature.com
Allopurinol is the most commonly prescribed urate-lowering therapy for the management of
gout. Serious adverse reactions associated with allopurinol, while rare, are feared owing to …

Allopurinol use and risk of fatal hypersensitivity reactions: a nationwide population-based study in Taiwan

CY Yang, CH Chen, ST Deng, CS Huang… - JAMA internal …, 2015 - jamanetwork.com
Importance Allopurinol, a first-line drug used for treating gout, is increasingly prescribed
worldwide to patients with asymptomatic hyperuricemia and comorbid renal or …

[PDF][PDF] Allopurinol hypersensitivity syndrome: a preventable severe cutaneous adverse reaction?

HY Lee, JTN Ariyasinghe, T Thirumoorthy - Singapore medical journal, 2008 - smj.org.sg
Introduction: Allopurinol is a widely-prescribed urate-lowering agent. Allopurinol
hypersensitivity syndrome, a severe form of cutaneous adverse reaction, is associated with …

Allopurinol hypersensitivity syndrome: a review

F Arellano, JA Sacristán - Annals of Pharmacotherapy, 1993 - journals.sagepub.com
OBJECTIVE: To review the pathophysiology, pathology, and clinical findings of allopurinol
hypersensitivity syndrome (AHS), an infrequent but life-threatening adverse effect of …

Allopurinol dosing in renal impairment: walking the tightrope between adequate urate lowering and adverse events

N Dalbeth, L Stamp - Seminars in dialysis, 2007 - Wiley Online Library
Allopurinol is the mainstay of urate‐lowering therapy for patients with gout and impaired
renal function. Although rare, a life‐threatening hypersensitivity syndrome may occur with …

Allopurinol hepatotoxicity is associated with human leukocyte antigen Class I alleles

RJ Fontana, YJ Li, E Phillips, N Saeed… - Liver …, 2021 - Wiley Online Library
Abstract Background/Aims Allopurinol can cause HLA class I‐associated life‐threatening
severe skin reactions. However, HLA risk and association with clinical features in allopurinol …