Cardiac valves function in a mechanically complex environment, opening and closing close
to a billion times during the average human lifetime, experiencing transvalvular pressures …

The aortic valve is highly responsive to cyclical and continuous mechanical forces, at the
macroscopic and cellular levels. In this report, we delineate mechanokinetics (effects of …

This review highlights aspects of calcific aortic valve disease that encompass the entire
range of aortic valve disease progression from initial cellular changes to aortic valve …

Calcific aortic valve disease (CAVD) is a common acquired valvulopathy, which carries a
high burden of mortality. Chronic inflammation has been postulated as the predominant …

Calcific aortic valve disease (CAVD) is the most common form of heart valve disease in
Western society and results in the second most common cardiovascular surgery performed …

Aortic valve leaflets experience varying applied loads during the cardiac cycle. These
varying loads act on both cell types of the leaflets, endothelial and interstitial cells, and …

The aortic valve (AV) experiences a complex mechanical environment, which includes
tension, flexure, pressure, and shear stress forces due to blood flow during each cardiac …

Heart valves control unidirectional blood flow within the heart during the cardiac cycle. They
have a remarkable ability to withstand the demanding mechanical environment of the heart …

The aortic valve, positioned between the left ventricle and aortic root, prevents retrograde
flow of blood into the ventricle during diastole. Opening and closing of the valve occurs …

Significance: Currently, calcific aortic valve disease (CAVD) is only treatable through
surgical intervention because the specific mechanisms leading to the disease remain …