Limited T cell receptor diversity of HCV-specific T cell responses is associated with CTL escape
D Meyer-Olson, NH Shoukry, KW Brady… - The Journal of …, 2004 - rupress.org
Escape mutations are believed to be important contributors to immune evasion by rapidly
evolving viruses such as hepatitis C virus (HCV). We show that the majority of HCV-specific …
evolving viruses such as hepatitis C virus (HCV). We show that the majority of HCV-specific …
[PDF][PDF] Selection‐driven immune escape is not a significant factor in the failure of CD4 T cell responses in persistent hepatitis C virus infection
MJ Fuller, NH Shoukry, T Gushima, DG Bowen… - …, 2010 - Wiley Online Library
Immune escape driven by selection pressure from virus‐specific CD8 T cells has been
demonstrated in both chimpanzees and humans infected with the hepatitis C virus (HCV) …
demonstrated in both chimpanzees and humans infected with the hepatitis C virus (HCV) …
[HTML][HTML] Mutational escape from CD8+ T cell immunity: HCV evolution, from chimpanzees to man
The mechanisms by which the hepatitis C virus (HCV) establishes persistence are not yet
fully understood. Previous chimpanzee and now human studies suggest that mutations …
fully understood. Previous chimpanzee and now human studies suggest that mutations …
Positive selection of cytotoxic T lymphocyte escape variants during acute hepatitis C virus infection
S Guglietta, AR Garbuglia, V Pacciani… - European journal of …, 2005 - Wiley Online Library
Cellular immune responses are induced during hepatitis C virus (HCV) infection and acute‐
phase CD8+ T cells are supposed to play an important role in controlling viral replication. In …
phase CD8+ T cells are supposed to play an important role in controlling viral replication. In …
[HTML][HTML] Stable cytotoxic T cell escape mutation in hepatitis C virus is linked to maintenance of viral fitness
L Uebelhoer, JH Han, B Callendret, G Mateu… - PLoS …, 2008 - journals.plos.org
Mechanisms by which hepatitis C virus (HCV) evades cellular immunity to establish
persistence in chronically infected individuals are not clear. Mutations in human leukocyte …
persistence in chronically infected individuals are not clear. Mutations in human leukocyte …
[PDF][PDF] The outcome of hepatitis C virus infection is predicted by escape mutations in epitopes targeted by cytotoxic T lymphocytes
AL Erickson, Y Kimura, S Igarashi, J Eichelberger… - Immunity, 2001 - cell.com
Abstract CD8+ cytotoxic T lymphocytes (CTL) are thought to control hepatitis C virus (HCV)
replication and so we investigated why this response fails in persistently infected individuals …
replication and so we investigated why this response fails in persistently infected individuals …
Escape mutations alter proteasome processing of major histocompatibility complex class I-restricted epitopes in persistent hepatitis C virus infection
Y Kimura, T Gushima, S Rawale, P Kaumaya… - Journal of …, 2005 - Am Soc Microbiol
Mutations in hepatitis C virus (HCV) genomes facilitate escape from virus-specific CD8+ T
lymphocytes in persistently infected chimpanzees. Our previous studies demonstrated that …
lymphocytes in persistently infected chimpanzees. Our previous studies demonstrated that …
Persistent hepatitis C virus infection in a chimpanzee is associated with emergence of a cytotoxic T lymphocyte escape variant.
A Weiner, AL Erickson, J Kansopon… - Proceedings of the …, 1995 - National Acad Sciences
Hepatitis C virus (HCV) establishes a persistent infection in humans and chimpanzees
despite the presence of virus-specific, class I major histocompatibility complex-restricted …
despite the presence of virus-specific, class I major histocompatibility complex-restricted …
Hepatitis C virus immune escape via exploitation of a hole in the T cell repertoire
M Wölfl, A Rutebemberwa, T Mosbruger… - The Journal of …, 2008 - journals.aai.org
Hepatitis C virus (HCV) infection frequently persists despite eliciting substantial virus-
specific immune responses. Thus, HCV infection provides a setting in which to investigate …
specific immune responses. Thus, HCV infection provides a setting in which to investigate …
Hepatitis C virus–T‐cell responses and viral escape mutations
D Petrovic, E Dempsey, DG Doherty… - European journal of …, 2012 - Wiley Online Library
Hepatitis C virus (HCV) is a small, enveloped RNA virus and the number of HCV‐infected
individuals worldwide is estimated to be approximately 170 million. Most HCV infections …
individuals worldwide is estimated to be approximately 170 million. Most HCV infections …