Osteopontin (OPN) is a multifunctional phosphorylated protein. It is widely involved in solid
tumor progression, such as intensification of macrophage recruitment, inhibition of T-cell …

Despite significant advances in the understanding of cancer biology, cancer is still a leading
cause of death worldwide. Expression of the tumor microenvironment component …

Context-dependent reciprocal crosstalk between cancer and surrounding stromal cells in the
tumor microenvironment is imperative for the regulation of various hallmarks of cancer. A …

Complex interactions between tumor and host cells regulate systemic tumor dissemination,
a process that begins early at the primary tumor site and goes on until tumor cells detach …

Abstract Secreted phosphoprotein 1 (spp1), the gene encoding osteopontin (OPN), is
expressed in many human carcinomas, although its in vivo functions remain unclear. To …

Osteopontin (OPN) is a chemokine like phosphorylated glycoprotein that plays important
role in cancer progression. Extensive research from various laboratories has demonstrated …

Simple Summary Anti-PD-1/PD-L1 and anti-CTLA-4-based immune checkpoint blockade
(ICB) immunotherapy have recently emerged as a breakthrough in human cancer treatment …

Introduction: Cancer is a complex pathological disorder, established as a result of
accumulation of genetic and epigenetic changes, which lead to adverse alterations in the …

Increasing evidence indicates that macrophages in tumor stroma can significantly modify the
malignant phenotypes of tumors. Osteopontin (OPN) is frequently overexpressed in cancers …

Cell migration and degradation of the extracellular matrix (ECM) are crucial steps in tumor
progression. Several matrix-degrading proteases, including matrix metalloproteases, are …