[HTML][HTML] Dysregulation of glutathione synthesis in liver disease

SC Lu - Liver Research, 2020 - Elsevier
Glutathione (GSH), a tripeptide that is present in all mammalian tissues, is especially highly
concentrated in the liver. GSH synthesis occurs via two adenosine triphosphate (ATP) …

Regulation of hepatic glutathione synthesis: current concepts and controversies

SC Lu - The FASEB journal, 1999 - Wiley Online Library
Glutathione (GSH) is an important intracellular peptide with multiple functions ranging from
antioxidant defense to modulation of cell proliferation. GSH is synthesized in the cytosol of …

Regulation of hepatic glutathione metabolism and its role in hepatotoxicity

M Kretzschmar - Experimental and Toxicologic Pathology, 1996 - Elsevier
The regulation of hepatic glutathione (GSH) metabolism have been reviewed. Key steps in
the regulation of hepatic GSH are GSH biosynthesis, the GSH-redox-cycle, the cystathionine …

Regulation of hepatic glutathione synthesis

SC Lu - Seminars in liver disease, 1998 - thieme-connect.com
Glutathione (GSH) is one of the most important intracellular peptides, playing a
multifunctional role ranging from antioxidant defense to modulation of immune function. GSH …

Changes in glutathione content in liver diseases: an update

M Vairetti, LG Di Pasqua, M Cagna, P Richelmi… - Antioxidants, 2021 - mdpi.com
Glutathione (GSH), a tripeptide particularly concentrated in the liver, is the most important
thiol reducing agent involved in the modulation of redox processes. It has also been …

[引用][C] The regulation of hepatic glutathione

N Kaplowitz, TY Aw, M Ookhtens - Annual review of …, 1985 - annualreviews.org
Glutathione (GSH) is a peptide composed of glutamate, cysteine, and glycine that exists in
thiol· reduced (GSH) and disulfide-oxidized (GSSG) forms. GSH has been the subject of …

Regulation of glutathione synthesis

SC Lu - Molecular aspects of medicine, 2009 - Elsevier
Glutathione (GSH) is a ubiquitous intracellular peptide with diverse functions that include
detoxification, antioxidant defense, maintenance of thiol status, and modulation of cell …

Glutathione metabolism and its role in hepatotoxicity

LD DeLeve, N Kaplowitz - Pharmacology & therapeutics, 1991 - Elsevier
Glutathione (GSH) fulfills several essential functions: Detoxification of free radicals and toxic
oxygen radicals, thiol-disulfide exchange and storage and transfer of cysteine. GSH is …

Glutathione dysregulation and the etiology and progression of human diseases

N Ballatori, SM Krance, S Notenboom, S Shi, K Tieu… - 2009 - degruyter.com
Glutathione (GSH) plays an important role in a multitude of cellular processes, including cell
differentiation, proliferation, and apoptosis, and as a result, disturbances in GSH …

Glutathione defense mechanism in liver injury: insights from animal models

Y Chen, H Dong, DC Thompson, HG Shertzer… - Food and chemical …, 2013 - Elsevier
Glutathione (GSH) is the most abundant cellular thiol antioxidant and it exhibits numerous
and versatile functions. Disturbances in GSH homeostasis have been associated with liver …