The efficient study of human disease requires the proper tools, one of the most crucial of
which is an accurate animal model that faithfully recapitulates the human condition. The …

Amyotrophic lateral sclerosis (ALS) is a fatal, multigenic, multifactorial, and non-cell
autonomous neurodegenerative disease characterized by upper and lower motor neuron …

Abstract Amyotrophic Lateral Sclerosis (ALS) is a motor neuron disease affecting upper and
lower motor neurons in the central nervous system. Patients with ALS develop extensive …

Amyotrophic lateral sclerosis (ALS) is a fatal adult-onset neurodegenerative disorder. There
are several genetic mutations that lead to ALS development, such as chromosome 9 …

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder that primarily affects the
motor system and presents with progressive muscle weakness. Most patients survive for …

In order to dissect amyotrophic lateral sclerosis (ALS), a multigenic, multifactorial, and
progressive neurodegenerative disease with heterogeneous clinical presentations …

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by the
selective death of motor neurons in the motor cortex, brainstem, and spinal cord. A large …

Amyotrophic lateral sclerosis is a complex disorder most of which is 'sporadic'of unknown
origin but approximately 10% is familial, arising from single mutations in any of more than 30 …

Abstract Amyotrophic Lateral Sclerosis (ALS) is a progressive, neurodegenerative disease
characterized by loss of upper motor neurons (UMN) and lower motor neurons (LMN) …

ABSTRACT A wide range of genetic mouse models is available to help researchers dissect
human disease mechanisms. Each type of model has its own distinctive characteristics …