It is now widely accepted that the normal immune system harbors a regulatory T‐cell
population specialized for immune suppression. It was found initially that some CD4+ T cells …

CD4+ CD25+ FOXP3+ regulatory T-cells (Tregs) form an important arm of the immune
system responsible for suppressing untoward immune responses. Tregs can be thymically …

Abstract Naturally arising CD25+ CD4+ regulatory T cells, which express the transcription
factor Foxp3, play key roles in themaintenance of immunologic self-tolerance and negative …

CD4+ CD25+ regulatory T (TR) cells have been described in both humans and mice. In
mice, TR are thymically derived, and lack of TR leads to organ-specific autoimmunity …

Regulatory T cells control immune responses to self-and foreign-antigens and play a major
role in maintaining the balance between immunity and tolerance. This article reviews recent …

Natural FOXP3+ CD25+ CD4+ regulatory T cells (Tregs) actively suppress pathological and
physiological immune responses, contributing to the maintenance of immunological self …

Any scientist opening up an immunology journal today will observe immediately that
suppressor T cells, renamed 'regulatory T cells'(Tregs) have become a central concept in the …

Abstract Naturally occurring CD25+ CD4+ regulatory T cells are engaged in the
maintenance of immunological self-tolerance and down-regulation of various immune …

Naturally arising CD25+ CD4+ regulatory T (Treg) cells, most of which are produced by the
normal thymus as a functionally mature T‐cell subpopulation, play key roles in the …

Early studies of mice subjected to neonatal thymectomy and analyses of adoptive T‐cell
transfer into lymphopenic hosts led to the identification of a specialized subset of regulatory …