Background: Daily opioid therapy is widely used in the treatment of chronic noncancer pain,
yet there is limited empirical evidence on the relationship of opioid dosing and health …

Purpose Long-term opioid use for chronic pain has increased, but limited evidence exists on
its benefits. Evaluation of long-term benefits in pain is based on patient-reported measures …

Objective: The use of opioids in the management of non-malignant pain remains
controversial. For many physicians, pain relief stemming from opioid use is not enough …

Objective The objective of this study was to investigate in a real-life context the effectiveness
of long-term opioid therapy for reducing pain intensity and interference and improving health …

Abstract Purpose Over 25 million Americans reported having daily pain and between 5 and
8 million Americans used opioids to treat chronic pain in 2012. This is the first systematic …

BACKGROUND: In Denmark, opioids have been used liberally for many years in the
treatment of non-malignant pain, but long-term consequences as tolerance and influence on …

Background Characteristics of patients receiving long-term opioid therapy (≥ 6 months) for
chronic noncancer pain are poorly understood. We conducted a cross-sectional survey of …

Objectives: Chronic opioid therapy (COT) is associated with various adverse outcomes,
especially at higher doses, yet little is known about predictors of sustained higher-dose COT …

Chronic opioid therapy is commonly prescribed for chronic nonmalignant pain. Few
published data describe the adverse effects experienced by patients with chronic …

Background and Objectives While research on the separate relationships between health‐
related quality of life (HRQOL) and chronic pain, and HRQOL and opioid abuse has been …