Major depression is one of the most common psychiatric disorders, and it often presents in
combination with other medical and psychiatric illnesses. In almost one third of cases, it …

Purpose Treatment‐resistant depression (TRD) can require complex management. The
purpose of this paper is to provide an update on the hypothesized neurobiology of …

Background. The failure to achieve remission for patients with Major Depressive Disorder
(MDD) represents a major public health concern. Inadequately treated depression is …

Depressive disorders are a leading cause of disability worldwide and greatly impact
morbidity, health care utilization, and medical costs. Major depression that does not resolve …

Treatment-resistant depression (TRD) is a major public health problem in terms of its
prevalence and in terms of individual suffering and cost to society. Best estimates indicate …

Although antidepressants have helped millions worldwide, a substantial proportion of
patients fail to respond or remit. There is little published information available to clinicians for …

Managing patients with treatment-resistant depression (TRD) remains a major challenge for
the practicing physician. Depression is considered treatment-resistant when at least two …

Introduction: Treatment-resistant depression (TRD) is a complex, multifactorial, and
biologically heterogeneous disorder with debilitating outcomes. Understanding individual …

Treatment-resistant depression (TRD) is a common clinical occurrence among patients
treated for major depressive disorder. However, a clear consensus regarding the criteria …

Treatment-resistant depression (TRD) presents many challenges for both patients and
physicians. This review aims to evaluate the current status of the field of TRD and reflects the …