Rationale: Based on surface brushings and bronchoalveolar lavage fluid, Hilty and
coworkers demonstrated microbiomes in the human lung characteristic of asthma and …

Rationale: The relatively sparse but diverse microbiome in human lungs may become less
diverse in chronic obstructive pulmonary disease (COPD). This article examines the …

Although culture-independent techniques have shown that the lungs are not sterile, little is
known about the lung microbiome in chronic obstructive pulmonary disease (COPD). We …

Culture of bacteria from bronchial secretions in respiratory patients has low sensitivity and
does not allow for complete assessment of microbial diversity across different bronchial …

Chronic obstructive pulmonary disease (COPD) is an inflammatory disorder characterized
by incompletely reversible airflow obstruction. Bacterial infection of the lower respiratory tract …

Rationale The role bacteria play in the progression of COPD has increasingly been
highlighted in recent years. However, the microbial community complexity in the lower …

Traditional culture techniques confirm that bacteria have an important role in C hronic O
bstructive P ulmonary D isease (COPD). In individuals with COPD, acquisition of novel …

Bronchial colonization by potentially pathogenic microorganisms (PPMs) is often
demonstrated in chronic obstructive pulmonary disease (COPD), but culture-based …

Background Oral taxa are often found in the chronic obstructive pulmonary disease (COPD)
lung microbiota, but it is not clear if this is due to a physiologic process such as aspiration or …

The healthy lung has previously been considered to be a sterile organ because standard
microbiological culture techniques consistently yield negative results. However, culture …