All HPV-negative head and neck cancers are not the same: Analysis of the TCGA dataset reveals that anatomical sites have distinct mutation, transcriptome, hypoxia …

HAJ Kim, PYF Zeng, MH Shaikh, N Mundi, F Ghasemi… - Oral Oncology, 2021 - Elsevier
Purpose Head and neck squamous cell carcinoma (HNSCC) affects various anatomical
sites, which often dictates whether the cancer is managed with primary surgery or radiation …

HPV33+ HNSCC is associated with poor prognosis and has unique genomic and immunologic landscapes

K Chatfield-Reed, S Gui, WQ O'Neill, TN Teknos, Q Pan - Oral oncology, 2020 - Elsevier
Objective To determine the influence of high-risk HPV genotype on outcomes in HNSCC
patients. Materials and Methods This is a retrospective analysis of The Cancer Genome …

Association of tumor site with the prognosis and immunogenomic landscape of human papillomavirus–related head and neck and cervical cancers

G Zhu, N Amin, ME Herberg, CA Maroun… - … –Head & Neck …, 2022 - jamanetwork.com
Importance Human papillomavirus (HPV)–positive status in patients with oropharyngeal
squamous cell carcinoma (OPSCC) is associated with improved survival compared with …

Integrative analysis of head and neck cancer identifies two biologically distinct HPV and three non-HPV subtypes

MK Keck, Z Zuo, A Khattri, TP Stricker, CD Brown… - Clinical cancer …, 2015 - AACR
Purpose: Current classification of head and neck squamous cell carcinomas (HNSCC)
based on anatomic site and stage fails to capture biologic heterogeneity or adequately …

[HTML][HTML] Targeted next-generation sequencing of head and neck squamous cell carcinoma identifies novel genetic alterations in HPV+ and HPV-tumors

M Lechner, GM Frampton, T Fenton, A Feber… - Genome medicine, 2013 - Springer
Background Human papillomavirus positive (HPV+) head and neck squamous cell
carcinoma (HNSCC) is an emerging disease, representing a distinct clinical and …

[HTML][HTML] Molecular landscape of head and neck cancer and implications for therapy

CS Farah - Annals of Translational Medicine, 2021 - ncbi.nlm.nih.gov
Head and neck squamous cell carcinomas (HNSCC) arising from the oral cavity, pharynx,
and larynx constitute the 6 th most common human cancer. Human papillomavirus (HPV) …

[HTML][HTML] Histoepigenetic analysis of HPV-and tobacco-associated head and neck cancer identifies both subtype-specific and common therapeutic targets despite …

I Carrero, HC Liu, AG Sikora, A Milosavljevic - Oncogene, 2019 - nature.com
Although head and neck squamous cell carcinoma (HNSCC) has in the past been largely
associated with tobacco use, human papillomavirus (HPV+) oropharynx cancer has in …

Mutation of chromatin regulators and focal hotspot alterations characterize human papillomavirus–positive oropharyngeal squamous cell carcinoma

S Haft, S Ren, G Xu, A Mark, K Fisch, TW Guo, Z Khan… - Cancer, 2019 - Wiley Online Library
Background Human papillomavirus (HPV)–associated oropharyngeal cancer is a disease
clinically and biologically distinct from smoking‐related head and neck squamous cell …

[HTML][HTML] Genotyping and characterization of HPV status, hypoxia, and radiosensitivity in 22 head and neck cancer cell lines

EL Göttgens, M Ansems, WPJ Leenders, J Bussink… - Cancers, 2021 - mdpi.com
Simple Summary Cell lines are widely used for research, but even commonly used cell lines
may not be well characterized, making validation of published data and generalizing the …

Biological features of human papillomavirus-related head and neck cancers contributing to improved response

C Cleary, JE Leeman, DS Higginson, N Katabi… - Clinical Oncology, 2016 - Elsevier
Head and neck squamous cell carcinomas (HNSCC) are the sixth most common malignancy
globally, and an increasing proportion of oropharyngeal HNSCCs are associated with the …