Dynamic alternative DNA structures in biology and disease
G Wang, KM Vasquez - Nature Reviews Genetics, 2023 - nature.com
Repetitive elements in the human genome, once considered 'junk DNA', are now known to
adopt more than a dozen alternative (that is, non-B) DNA structures, such as self-annealed …
adopt more than a dozen alternative (that is, non-B) DNA structures, such as self-annealed …
Non-B DNA structure-induced genetic instability
G Wang, KM Vasquez - Mutation Research/Fundamental and Molecular …, 2006 - Elsevier
Repetitive DNA sequences are abundant in eukaryotic genomes, and many of these
sequences have the potential to adopt non-B DNA conformations. Genes harboring non-B …
sequences have the potential to adopt non-B DNA conformations. Genes harboring non-B …
[HTML][HTML] Detection of alternative DNA structures and its implications for human disease
G Matos-Rodrigues, JA Hisey, A Nussenzweig… - Molecular Cell, 2023 - cell.com
Around 3% of the genome consists of simple DNA repeats that are prone to forming
alternative (non-B) DNA structures, such as hairpins, cruciforms, triplexes (H-DNA), four …
alternative (non-B) DNA structures, such as hairpins, cruciforms, triplexes (H-DNA), four …
Non‐B DNA conformations as determinants of mutagenesis and human disease
A Bacolla, RD Wells - … in cooperation with the University of …, 2009 - Wiley Online Library
Repetitive DNA motifs may fold into non‐B DNA structures, including cruciforms/hairpins,
triplexes, slipped conformations, quadruplexes, and left‐handed Z‐DNA, thereby …
triplexes, slipped conformations, quadruplexes, and left‐handed Z‐DNA, thereby …
Non-B DNA structure-induced genetic instability and evolution
J Zhao, A Bacolla, G Wang, KM Vasquez - Cellular and molecular life …, 2010 - Springer
Repetitive DNA motifs are abundant in the genomes of various species and have the
capacity to adopt non-canonical (ie, non-B) DNA structures. Several non-B DNA structures …
capacity to adopt non-canonical (ie, non-B) DNA structures. Several non-B DNA structures …
DNA secondary structures: stability and function of G-quadruplex structures
ML Bochman, K Paeschke, VA Zakian - Nature Reviews Genetics, 2012 - nature.com
In addition to the canonical double helix, DNA can fold into various other inter-and
intramolecular secondary structures. Although many such structures were long thought to be …
intramolecular secondary structures. Although many such structures were long thought to be …
Impact of alternative DNA structures on DNA damage, DNA repair, and genetic instability
G Wang, KM Vasquez - DNA repair, 2014 - Elsevier
Repetitive genomic sequences can adopt a number of alternative DNA structures that differ
from the canonical B-form duplex (ie non-B DNA). These non-B DNA-forming sequences …
from the canonical B-form duplex (ie non-B DNA). These non-B DNA-forming sequences …
Non-canonical DNA structures: Diversity and disease association
A complete understanding of DNA double-helical structure discovered by James Watson
and Francis Crick in 1953, unveil the importance and significance of DNA. For the last seven …
and Francis Crick in 1953, unveil the importance and significance of DNA. For the last seven …
The intrinsically unstable life of DNA triplet repeats associated with human hereditary disorders
RP Bowater, RD Wells - 2000 - Elsevier
Expansions of specific DNA triplet repeats are the cause of an increasing number of
hereditary neurological disorders in humans. In some diseases, such as Huntington's and …
hereditary neurological disorders in humans. In some diseases, such as Huntington's and …
Alternative DNA Structures In Vivo: Molecular Evidence and Remaining Questions
L Poggi, GF Richard - Microbiology and Molecular Biology …, 2021 - Am Soc Microbiol
Duplex DNA naturally folds into a right-handed double helix in physiological conditions.
Some sequences of unusual base composition may nevertheless form alternative structures …
Some sequences of unusual base composition may nevertheless form alternative structures …