Bionic functional coating plays a pivotal role in promoting internal fixation treatment of bone
fracture. However, post-traumatic microenvironment characterized by hypoxia and acidic …

An ideal implant needs to have the ability to coordinate the foreign body response and
tissue regeneration. Here, Hydrogenated‐silicon nanosheets (H‐Si NSs) with favorable …

Immediate mechanical stability is a prerequisite for fracture healing. In addition to bringing
immediate mechanical stability in fracture site, implants with bioactive coating can release …

Advancing bone implant engineering offers the opportunity to overcome crucial medical
challenges and improve clinical outcomes. Although the establishment of a functional …

The immune system and skeletal system are closely linked. Macrophages are one of the
most important immune cells for bone remodeling, playing a prohealing role mainly through …

Although most bone fractures typically heal without complications, a small proportion of
patients (≤ 10%) experience delayed healing or potential progression to non-union …

Fracture nonunion can result in considerable physical harm and limitation of quality of life in
patients, exerting an extensive economic burden to the society. Nonunion largely results …

The reconstruction of a large bone defect to an extent that exceeds its self-healing capacity
has been a great clinical challenge. In pursuit of this goal, a biomaterial-based scaffold that …

Composite scaffolds of nano-hydroxyapatite (nHAp) and silk fibroin (SF) have been reported
to promote bone regeneration mainly through signaling pathways associated with cell …

Stem cell-based therapy has drawn attention as an alternative option for promoting
prosthetic osteointegration in osteoporosis by virtue of its unique characteristics. However …