Inflammation involves a coordinated, sequential, and self limiting sequence of events
controlled by positive and negative regulatory mechanisms. Recent studies have shown that …

The mammalian inflammatory response is a rapid and complex physiological reaction to
noxious stimuli including microbial pathogens. Although inflammation plays a valuable role …

Macrophages respond to external stimuli with rapid changes in expression of many genes.
Different combinations of external stimuli lead to distinct polarized activation patterns …

IL-10 is a potent anti-inflammatory molecule that, in phagocytes, negatively targets cytokine
expression at transcriptional and posttranscriptional levels. Posttranscriptional checkpoints …

microRNAs are small noncoding RNAs that regulate protein-coding genes via
posttranscriptional repression. Most protein-coding genes are subjected to microRNA …

The mammalian inflammatory response to infection involves the induction of several
hundred genes, a process that must be carefully regulated to achieve pathogen clearance …

Chronic inflammation is involved in the onset and development of many diseases, including
obesity, atherosclerosis, type 2 diabetes, osteoarthritis, autoimmune and degenerative …

Inflammation is a biological response of the immune system to various insults, such as
pathogens, toxic compounds, damaged cells, and radiation. The complex network of pro …

Inflammation is essential to combat invading microbial pathogens. In this process, the
involvement of multiple immune cell populations is crucial in mounting an optimum immune …

Activation of mammalian innate and acquired immune responses must be tightly regulated
by elaborate mechanisms to control their onset and termination. MicroRNAs have been …