Ischemic stroke is the leading cause of globe death and permanent disability, but its
therapeutic strategies are limited. Over the past decades, multiprotein complexes called …

Ischemic stroke is one of the main causes of serious disability and death worldwide. NLRP3
inflammasome is an intracellular pattern recognition receptor composed of polyprotein …

Stroke is one of the major devastating diseases with no effective medical therapeutics.
Because of the high rate of disability and mortality among stroke patients, new treatments …

Ischemic stroke patients suffer from relatively limited treatment options. Studies have shown
that in cerebral ischemia, NOD-like receptor family pyrin domain containing 3 (NLRP3) …

Activation of the NOD-like receptor protein (NLRP3)-inflammasome has been postulated to
mediate inflammatory responses to brain damage during ischemic/reperfusion (I/R) injury …

Inflammation is thought to play an important role in the pathophysiology of ischaemic stroke,
which is a main cause of disability and morbidity worldwide. Inhibition of the NOD‑like …

Ischemic stroke (IS) is a major cause of mortality and disability among adults. Recanalization
of blood vessels to facilitate timely reperfusion is the primary clinical approach; however …

Acute ischemic stroke is a severe condition that a vessel supplying blood to the brain is
abruptly blocked mostly due to cerebral thrombosis and embolism. There is a dearth of the …

The most effective way to contain cerebral ischemic injury is reperfusion; however,
reperfusion itself may result in tissue injury, for which inflammatory damage is one of the …

Stroke is one of the leading causes of death and disability worldwide. NLRP3 inflammasome
has an essential role in the neuropathology of stroke. Recent studies report that shifting the …