Aggregation Behavior and Inner Structure of Nanoparticles from Trypsin and Chondroitin Sulfate in a Wide pH Range–Implications for the Design of Biocompatible …

J Allwang, S Da Vela, A Chroni… - ACS Applied Nano …, 2023 - ACS Publications
Nanoparticles having a radius of ca. 200 nm are prepared from the proteolytic enzyme
trypsin (TRY) and the anionic polysaccharide chondroitin sulfate (CS) by electrostatic …

The role of hyaluronic acid inclusion on the energetics of encapsulation and release of a protein molecule from chitosan-based nanoparticles

S Al-Qadi, M Alatorre-Meda, M Martin-Pastor… - Colloids and Surfaces B …, 2016 - Elsevier
The synergistic effects of the polysaccharides chitosan (CS) and hyaluronic acid (HA)
formulated into hybrid nanoparticles are promising for drug delivery. In the present work, we …

Controlling the complexation of polysaccharides into multi-functional colloidal assemblies for nanomedicine

M Costalat, P Alcouffe, L David, T Delair - Journal of colloid and interface …, 2014 - Elsevier
The controlled assembly of oppositely charged polysaccharides led to colloids stable in
physiological media, capable of encapsulating a molecular drug and of sorbing proteins at …

Preparation of trypsin-based nanoparticles, colloidal properties and ability to bind bioactive compounds

A Papagiannopoulos, D Selianitis, A Chroni… - International Journal of …, 2022 - Elsevier
Nanoparticles (NPs) based on the proteolytic enzyme trypsin (TRY) were prepared by a
biocompatible methodology. TRY co-assembled with the anionic polysaccharide chondroitin …

Chitosan-based nanocapsules: Physical characterization, stability in biological media and capsaicin encapsulation

FM Goycoolea, A Valle-Gallego, R Stefani… - Colloid and Polymer …, 2012 - Springer
This study addresses the effect of the degree of N-acetylation (DA~ 1.4–56%) of chitosan
(CS) of low and medium molecular weight (M w~ 9.5–13.2 and~ 122–266 kDa, respectively) …

Chitosan nanoparticles as therapeutic protein nanocarriers: The effect of ph on particle formation and encapsulation efficiency

C Mattu, R Li, G Ciardelli - Polymer composites, 2013 - Wiley Online Library
In the past, tripolyphosphate (TPP)‐crosslinked chitosan (CS) nanoparticles (CSNPs) have
been widely applied for the delivery of biomacromolecules, because of their mild …

Media-dependent morphology of supramolecular aggregates of β-cyclodextrin-grafted chitosan and insulin through multivalent interactions

Y Daimon, H Izawa, K Kawakami, P Żywicki… - Journal of Materials …, 2014 - pubs.rsc.org
A supramolecular protein-binding system based on multivalent interactions was investigated
using β-cyclodextrin-grafted chitosan (BCC) and insulin. 1H NMR and fluorescence …

Understanding the stability of nanoparticle–protein interactions: effect of particle size on adsorption, conformation and thermodynamic properties of serum albumin …

M Suvarna, S Dyawanapelly, B Kansara… - ACS Applied Nano …, 2018 - ACS Publications
The present work evaluates the effect of nanoparticle size on the structure and function of
albumin proteins. Further, the work evaluates the nature of binding between low molecular …

Polysaccharide nanoparticles for protein and Peptide delivery: exploring less-known materials

MA Dos Santos, A Grenha - Advances in protein chemistry and structural …, 2015 - Elsevier
Finding adequate carriers for protein and peptide delivery has become an urgent need,
owing to the growing number of macromolecules identified as having therapeutic potential …

pH variation as a simple and selective pathway for obtaining nanoparticle or nanocapsule polysaccharides

C Pitakchatwong, S Chirachanchai - Langmuir, 2018 - ACS Publications
The fabrication of polysaccharides to be nanoparticles or nanocapsules is quite specific due
to various parameters and factors. The present work demonstrates a simple pathway to …