Glycosynthases, engineered glycoside hydrolases that are able to synthesize glycans in
quantitative yields without hydrolyzing them, are among the most interesting tools for the …

In oligosaccharide synthesis the chemo‐enzymatic approach is often chosen to obtain the
desired glycosidic bond by exploiting the exquisite substrate specificity and stereoselectivity …

The mutation of putative acid/base and nucleophile of the active sites of retaining glycosyl
hydrolases, together with kinetic analysis of the mutants, and stereochemical identification of …

The many advances in glycoscience have more and more brought to light the crucial role of
glycosides and glycoconjugates in biological processes. Their major influence on the …

Oligosaccharide synthesis is becoming increasingly important to the pharmaceutical
industry because these biomolecules have potential application as therapeutics. Enzymatic …

Retaining glycosidases have been extensively studied for the synthesis of oligosaccharides
and glycoconjugates as a convenient enzymatic approach to achieve the required regio-and …

Enzymes are indispensable tools in modern organic synthesis. Recent progress in cloning
techniques, microbiology and protein purification supply an ever growing number and …

Carbohydrate related enzymes, like glycosyltransferases and glycoside hydrolases, are
nowadays more easily accessible and are thought to represent powerful and greener …

Remarkable advances in glycobiology in recent years have stimulated a resurgence of
interest in carbohydrate chemistry. The challenge of producing the complex glycosides and …

Glycosynthases are engineered mutant glycosidases that catalyse the formation of a
glycosidic bond from a glycosyl donor and an acceptor alcohol. They are constructed by …