A review of brain atrophy subtypes definition and analysis for Alzheimer's disease heterogeneity studies

B Zhang, L Lin, S Wu - Journal of Alzheimer's Disease, 2021 - content.iospress.com
Alzheimer's disease (AD) is a heterogeneous disease with different subtypes. Studying AD
subtypes from brain structure, neuropathology, and cognition are of great importance for AD …

[HTML][HTML] Robust identification of Alzheimer's disease subtypes based on cortical atrophy patterns

JY Park, HK Na, S Kim, H Kim, HJ Kim, SW Seo… - Scientific reports, 2017 - nature.com
Accumulating evidence suggests that Alzheimer's disease (AD) is heterogenous and can be
classified into several subtypes. Here, we propose a robust subtyping method for AD based …

Heterogeneous patterns of brain atrophy in Alzheimer's disease

K Poulakis, JB Pereira, P Mecocci, B Vellas… - Neurobiology of …, 2018 - Elsevier
There is increasing evidence showing that brain atrophy varies between patients with
Alzheimer's disease (AD), suggesting that different anatomical patterns might exist within the …

[HTML][HTML] Heterogeneity of regional brain atrophy patterns associated with distinct progression rates in Alzheimer's disease

MS Byun, SE Kim, J Park, D Yi, YM Choe, BK Sohn… - PLoS …, 2015 - journals.plos.org
We aimed to identify and characterize subtypes of Alzheimer's disease (AD) exhibiting
different patterns of regional brain atrophy on MRI using age-and gender-specific norms of …

[HTML][HTML] Distinct subtypes of Alzheimer's disease based on patterns of brain atrophy: longitudinal trajectories and clinical applications

D Ferreira, C Verhagen, JA Hernández-Cabrera… - Scientific reports, 2017 - nature.com
Atrophy patterns on MRI can reliably predict three neuropathological subtypes of
Alzheimer's disease (AD): typical, limbic-predominant, or hippocampal-sparing. A method to …

Atrophy subtypes in prodromal Alzheimer's disease are associated with cognitive decline

M Ten Kate, E Dicks, PJ Visser, WM van der Flier… - Brain, 2018 - academic.oup.com
Alzheimer's disease is a heterogeneous disorder. Understanding the biological basis for this
heterogeneity is key for developing personalized medicine. We identified atrophy subtypes …

Comparison of subtyping methods for neuroimaging studies in Alzheimer's disease: a call for harmonization

R Mohanty, G Mårtensson, K Poulakis… - Brain …, 2020 - academic.oup.com
Biological subtypes in Alzheimer's disease, originally identified on neuropathological data,
have been translated to in vivo biomarkers such as structural magnetic resonance imaging …

[HTML][HTML] Multiple subtypes of Alzheimer's disease base on brain atrophy pattern

B Zhang, L Lin, S Wu, ZHMA Al-Masqari - Brain sciences, 2021 - mdpi.com
Alzheimer's disease (AD) is a disease of a heterogeneous nature, which can be
disentangled by exploring the characteristics of each AD subtype in the brain structure …

Biological subtypes of Alzheimer disease: a systematic review and meta-analysis

D Ferreira, A Nordberg, E Westman - Neurology, 2020 - AAN Enterprises
Objective To test the hypothesis that distinct subtypes of Alzheimer disease (AD) exist and
underlie the heterogeneity within AD, we conducted a systematic review and meta-analysis …

A review of neuroimaging-based data-driven approach for Alzheimer's disease heterogeneity analysis

L Liu, S Sun, W Kang, S Wu, L Lin - Reviews in the Neurosciences, 2024 - degruyter.com
Alzheimer's disease (AD) is a complex form of dementia and due to its high phenotypic
variability, its diagnosis and monitoring can be quite challenging. Biomarkers play a crucial …