Osteoarthritis—the most common form of age-related degenerative whole-joint disease—is
primarily characterized by cartilage destruction, as well as by synovial inflammation …

The avascular nature of cartilage makes it a unique tissue,,–, but whether and how the
absence of nutrient supply regulates chondrogenesis remain unknown. Here we show that …

Oxysterols are cholesterol metabolites that serve multiple functions in lipid metabolism,
including as liver X receptor (LXR) ligands. 27-hydroxycholesterol (27HC) is an abundant …

Cholesterol homeostasis plays a significant role in skeletal development and the
dysregulation of cholesterol-related mechanism has been shown to be involved in the …

Altered lipid metabolism has been implicated as a critical player in osteoarthritis (OA). Our
study aimed to investigate the expression of genes regulating cholesterol efflux in human …

Osteoarthritis (OA) is an age-related degenerative disease comprising the main reason of
handicap in the Western world. Interestingly, to date, there are neither available biomarkers …

Osteoporosis and age-related bone loss are important public health concerns. Therefore,
there is a high level of interest in the development of medical interventions and lifestyle …

Several lines of research indicate that osteoarthritis (OA) is not only a joint disorder
associated with mechanical stress and aging but also a 'metabolic syndrome'in which …

Objective Hypercholesterolaemia, a risk factor for atherosclerosis (ATH), has been
suggested to have a role in the development of osteoarthritis (OA). To test this hypothesis …

Osteoclasts are bone-resorbing cells derived from hematopoietic precursors of the monocyte-
macrophage lineage. Regulation of osteoclast function is central to the understanding of …