The CH25H–CYP7B1–RORα axis of cholesterol metabolism regulates osteoarthritis
WS Choi, G Lee, WH Song, JT Koh, J Yang, JS Kwak… - Nature, 2019 - nature.com
Osteoarthritis—the most common form of age-related degenerative whole-joint disease—is
primarily characterized by cartilage destruction, as well as by synovial inflammation …
primarily characterized by cartilage destruction, as well as by synovial inflammation …
Lipid availability determines fate of skeletal progenitor cells via SOX9
N Van Gastel, S Stegen, G Eelen, S Schoors, A Carlier… - Nature, 2020 - nature.com
The avascular nature of cartilage makes it a unique tissue,,–, but whether and how the
absence of nutrient supply regulates chondrogenesis remain unknown. Here we show that …
absence of nutrient supply regulates chondrogenesis remain unknown. Here we show that …
[HTML][HTML] The cholesterol metabolite 27-hydroxycholesterol promotes atherosclerosis via proinflammatory processes mediated by estrogen receptor alpha
M Umetani, P Ghosh, T Ishikawa, J Umetani, M Ahmed… - Cell metabolism, 2014 - cell.com
Oxysterols are cholesterol metabolites that serve multiple functions in lipid metabolism,
including as liver X receptor (LXR) ligands. 27-hydroxycholesterol (27HC) is an abundant …
including as liver X receptor (LXR) ligands. 27-hydroxycholesterol (27HC) is an abundant …
Cholesterol metabolism related genes in osteoarthritis
I Papathanasiou, L Anastasopoulou, A Tsezou - Bone, 2021 - Elsevier
Cholesterol homeostasis plays a significant role in skeletal development and the
dysregulation of cholesterol-related mechanism has been shown to be involved in the …
dysregulation of cholesterol-related mechanism has been shown to be involved in the …
Impaired expression of genes regulating cholesterol efflux in human osteoarthritic chondrocytes
A Tsezou, D Iliopoulos, KN Malizos… - Journal of …, 2010 - Wiley Online Library
Altered lipid metabolism has been implicated as a critical player in osteoarthritis (OA). Our
study aimed to investigate the expression of genes regulating cholesterol efflux in human …
study aimed to investigate the expression of genes regulating cholesterol efflux in human …
Lipid metabolism and osteoarthritis: lessons from atherosclerosis
Osteoarthritis (OA) is an age-related degenerative disease comprising the main reason of
handicap in the Western world. Interestingly, to date, there are neither available biomarkers …
handicap in the Western world. Interestingly, to date, there are neither available biomarkers …
The oxysterol, 27-hydroxycholesterol, links cholesterol metabolism to bone homeostasis through its actions on the estrogen and liver X receptors
ER Nelson, CD DuSell, X Wang, MK Howe… - …, 2011 - academic.oup.com
Osteoporosis and age-related bone loss are important public health concerns. Therefore,
there is a high level of interest in the development of medical interventions and lifestyle …
there is a high level of interest in the development of medical interventions and lifestyle …
Cholesterol metabolism in pathogenesis of osteoarthritis disease
Several lines of research indicate that osteoarthritis (OA) is not only a joint disorder
associated with mechanical stress and aging but also a 'metabolic syndrome'in which …
associated with mechanical stress and aging but also a 'metabolic syndrome'in which …
Osteoarthritis development is induced by increased dietary cholesterol and can be inhibited by atorvastatin in APOE* 3Leiden. CETP mice—a translational model for …
LM Gierman, S Kühnast, A Koudijs… - Annals of the …, 2014 - ard.bmj.com
Objective Hypercholesterolaemia, a risk factor for atherosclerosis (ATH), has been
suggested to have a role in the development of osteoarthritis (OA). To test this hypothesis …
suggested to have a role in the development of osteoarthritis (OA). To test this hypothesis …
PPAR-γ regulates osteoclastogenesis in mice
Osteoclasts are bone-resorbing cells derived from hematopoietic precursors of the monocyte-
macrophage lineage. Regulation of osteoclast function is central to the understanding of …
macrophage lineage. Regulation of osteoclast function is central to the understanding of …