Mineralocorticoid receptor-antagonism prevents COVID-19-dependent glycocalyx damage

B Fels, S Acharya, C Vahldieck, T Graf… - … -European Journal of …, 2022 - Springer
Proinflammatory cytokines target vascular endothelial cells during COVID-19 infections. In
particular, the endothelial glycocalyx (eGC), a proteoglycan-rich layer on top of endothelial …

Protecting the endothelial glycocalyx in COVID-19

EA Tay, V Vijayakumar, RF Morales, ES Lee… - Plos …, 2024 - journals.plos.org
COVID-19 is a respiratory infection caused by the highly transmissible SARS-CoV-2. While
most infected patients exhibit mild to moderate symptoms, a minority may develop severe …

Glycocalyx as possible limiting factor in COVID-19

PP Wadowski, B Jilma, CW Kopp, S Ertl… - Frontiers in …, 2021 - frontiersin.org
The coronavirus disease 2019 (COVID-19) has emerged as a global burden comprising
cardiovascular and respiratory complications. Herein, endothelial cell infection causing …

Vascular endothelial injury exacerbates coronavirus disease 2019: The role of endothelial glycocalyx protection

H Okada, S Yoshida, A Hara, S Ogura… - …, 2021 - Wiley Online Library
The potential for a rapid increase in severity is among the most frightening aspects of severe
acute respiratory syndrome coronavirus 2 infection. Evidence increasingly suggests that the …

Interleukin-6 drives endothelial glycocalyx damage in COVID-19 and bacterial sepsis

CC Drost, A Rovas, I Osiaevi, K Schughart, A Lukasz… - Angiogenesis, 2024 - Springer
Damage of the endothelial glycocalyx (eGC) plays a central role in the development of
vascular hyperpermeability and organ damage during systemic inflammation. However, the …

Vascular endothelial glycocalyx damage and potential targeted therapy in COVID-19

D Zha, M Fu, Y Qian - Cells, 2022 - mdpi.com
COVID-19 is a highly infectious respiratory disease caused by a new coronavirus known as
SARS-CoV-2. COVID-19 is characterized by progressive respiratory failure resulting from …

Heparin prevents in vitro glycocalyx shedding induced by plasma from COVID-19 patients

SR Potje, TJ Costa, TFC Fraga-Silva, RB Martins… - Life sciences, 2021 - Elsevier
The severe forms and worsened outcomes of COVID-19 (coronavirus disease 19) are
closely associated with hypertension and cardiovascular disease. Endothelial cells express …

Efficacy of synthetic glucocorticoids in COVID-19 endothelites

F Ferrara, A Vitiello - Naunyn-schmiedeberg's Archives of Pharmacology, 2021 - Springer
Since March 2020, the world has been fighting a global pandemic caused by a new
coronavirus SARS-CoV-2 (COVID-19). SARS-CoV-2 is responsible for severe acute …

Extensive blood transcriptome analysis reveals cellular signaling networks activated by circulating glycocalyx components reflecting vascular injury in COVID-19

M Borrmann, F Brandes, B Kirchner, M Klein… - Frontiers in …, 2023 - frontiersin.org
Background Degradation of the endothelial protective glycocalyx layer during COVID-19
infection leads to shedding of major glycocalyx components. These circulating proteins and …

Immune-mediated glycocalyx remodeling in hospitalized COVID-19 patients

SN Goonewardena, OG Grushko, J Wells… - … Drugs and Therapy, 2021 - Springer
Purpose Vascular and immune dysfunction are hallmarks of severe acute respiratory
syndrome coronavirus-2 (SARS-CoV-2) infections and coronavirus disease 2019 (COVID …