The structural and functional workings of KEOPS
J Beenstock, F Sicheri - Nucleic Acids Research, 2021 - academic.oup.com
Abstract KEOPS (K inase, E ndopeptidase and O ther P roteins of S mall size) is a five-
subunit protein complex that is highly conserved in eukaryotes and archaea and is essential …
subunit protein complex that is highly conserved in eukaryotes and archaea and is essential …
[HTML][HTML] A substrate binding model for the KEOPS tRNA modifying complex
The KEOPS complex, which is conserved across archaea and eukaryotes, is composed of
four core subunits; Pcc1, Kae1, Bud32 and Cgi121. KEOPS is crucial for the fitness of all …
four core subunits; Pcc1, Kae1, Bud32 and Cgi121. KEOPS is crucial for the fitness of all …
Proteomic analysis of the human KEOPS complex identifies C14ORF142 as a core subunit homologous to yeast Gon7
LCK Wan, P Maisonneuve, RK Szilard… - Nucleic acids …, 2017 - academic.oup.com
The KEOPS/EKC complex is a tRNA modification complex involved in the biosynthesis of N6-
threonylcarbamoyladenosine (t6A), a universally conserved tRNA modification found on …
threonylcarbamoyladenosine (t6A), a universally conserved tRNA modification found on …
Crystal structures of the Gon7/Pcc1 and Bud32/Cgi121 complexes provide a model for the complete yeast KEOPS complex
The yeast KEOPS protein complex comprising Kae1, Bud32, Cgi121, Pcc1 and Gon7 is
responsible for the essential tRNA threonylcarbamoyladenosine (t6A) modification. Deletion …
responsible for the essential tRNA threonylcarbamoyladenosine (t6A) modification. Deletion …
Structural and functional characterization of KEOPS dimerization by Pcc1 and its role in t6A biosynthesis
LCK Wan, MC Pillon, N Thevakumaran… - Nucleic acids …, 2016 - academic.oup.com
KEOPS is an ancient protein complex required for the biosynthesis of N6-
threonylcarbamoyladenosine (t6A), a universally conserved tRNA modification found on all …
threonylcarbamoyladenosine (t6A), a universally conserved tRNA modification found on all …
KEOPS complex promotes homologous recombination via DNA resection
MH He, JC Liu, YS Lu, ZJ Wu, YY Liu, Z Wu… - Nucleic acids …, 2019 - academic.oup.com
KEOPS complex is one of the most conserved protein complexes in eukaryotes. It plays
important roles in both telomere uncapping and tRNA N6-threonylcarbamoyladenosine (t6A) …
important roles in both telomere uncapping and tRNA N6-threonylcarbamoyladenosine (t6A) …
[HTML][HTML] A paralog of Pcc1 is the fifth core subunit of the KEOPS tRNA-modifying complex in Archaea
MC Daugeron, S Missoury, V Da Cunha… - Nature …, 2023 - nature.com
Abstract In Archaea and Eukaryotes, the synthesis of a universal tRNA modification, N6-
threonyl-carbamoyl adenosine (t6A), is catalyzed by the KEOPS complex composed of …
threonyl-carbamoyl adenosine (t6A), is catalyzed by the KEOPS complex composed of …
Gcn4 misregulation reveals a direct role for the evolutionary conserved EKC/KEOPS in the t6A modification of tRNAs
MC Daugeron, TL Lenstra, M Frizzarin… - Nucleic acids …, 2011 - academic.oup.com
The EKC/KEOPS complex is universally conserved in Archaea and Eukarya and has been
implicated in several cellular processes, including transcription, telomere homeostasis and …
implicated in several cellular processes, including transcription, telomere homeostasis and …
[HTML][HTML] Defects in t6A tRNA modification due to GON7 and YRDC mutations lead to Galloway-Mowat syndrome
C Arrondel, S Missoury, R Snoek, J Patat… - Nature …, 2019 - nature.com
N6-threonyl-carbamoylation of adenosine 37 of ANN-type tRNAs (t6A) is a universal
modification essential for translational accuracy and efficiency. The t6A pathway uses two …
modification essential for translational accuracy and efficiency. The t6A pathway uses two …
An archaeal orthologue of the universal protein Kae1 is an iron metalloprotein which exhibits atypical DNA-binding properties and apurinic-endonuclease activity in …
Abstract The Kae1 (Kinase-associated endopeptidase 1) protein is a member of the recently
identified transcription complex EKC and telomeres maintenance complex KEOPS in yeast …
identified transcription complex EKC and telomeres maintenance complex KEOPS in yeast …