Parallel evolution of cannabinoid biosynthesis

P Berman, LA de Haro, A Jozwiak, S Panda, Z Pinkas… - Nature plants, 2023 - nature.com
Modulation of the endocannabinoid system is projected to have therapeutic potential in
almost all human diseases. Accordingly, the high demand for novel cannabinoids stimulates …

[HTML][HTML] Phytocannabinoids: origins and biosynthesis

T Gülck, BL Møller - Trends in plant science, 2020 - cell.com
Phytocannabinoids are bioactive natural products found in some flowering plants, liverworts,
and fungi that can be beneficial for the treatment of human ailments such as pain, anxiety …

Designing microorganisms for heterologous biosynthesis of cannabinoids

 Carvalho, EH Hansen, O Kayser… - FEMS yeast …, 2017 - academic.oup.com
During the last decade, the use of medical Cannabis has expanded globally and legislation
is getting more liberal in many countries, facilitating the research on cannabinoids. The …

Synthetic Biology of Cannabinoids and Cannabinoid Glucosides in Nicotiana benthamiana and Saccharomyces cerevisiae

T Gülck, JK Booth, Â Carvalho… - Journal of Natural …, 2020 - ACS Publications
Phytocannabinoids are a group of plant-derived metabolites that display a wide range of
psychoactive as well as health-promoting effects. The production of pharmaceutically …

A bio-inspired cell-free system for cannabinoid production from inexpensive inputs

MA Valliere, TP Korman, MA Arbing… - Nature Chemical …, 2020 - nature.com
Moving cannabinoid production away from the vagaries of plant extraction and into
engineered microbes could provide a consistent, purer, cheaper and environmentally …

Complete biosynthesis of cannabinoids and their unnatural analogues in yeast

X Luo, MA Reiter, L d'Espaux, J Wong, CM Denby… - Nature, 2019 - nature.com
Cannabis sativa L. has been cultivated and used around the globe for its medicinal
properties for millennia 1. Some cannabinoids, the hallmark constituents of Cannabis, and …

Cannabinoids: biosynthesis and biotechnological applications

S Sirikantaramas, F Taura - Cannabis sativa L.-Botany and biotechnology, 2017 - Springer
Cannabinoids are unique terpenophenolic metabolites found only in Cannabis sativa. The
biosynthetic mechanism of these compounds had long been ambiguous since conventional …

Comprehending and improving cannabis specialized metabolism in the systems biology era

P Romero, A Peris, K Vergara, JT Matus - Plant Science, 2020 - Elsevier
Cannabis sativa is a source of food, fiber and specialized metabolites such as cannabinoids,
with psychoactive and pharmacological effects. Due to its expanding and increasingly …

Origin and evolution of the cannabinoid oxidocyclase gene family

R van Velzen, ME Schranz - Genome Biology and Evolution, 2021 - academic.oup.com
Cannabis is an ancient crop representing a rapidly increasing legal market, especially for
medicinal purposes. Medicinal and psychoactive effects of Cannabis rely on specific …

A physical and genetic map of Cannabis sativa identifies extensive rearrangements at the THC/CBD acid synthase loci

KU Laverty, JM Stout, MJ Sullivan, H Shah… - Genome …, 2019 - genome.cshlp.org
Cannabis sativa is widely cultivated for medicinal, food, industrial, and recreational use, but
much remains unknown regarding its genetics, including the molecular determinants of …