CMX001 (phosphonic acid,[[(S)-2-(4-amino-2-oxo-1 (2H)-pyrimidinyl)-1-(hydroxymethyl)
ethoxy] methyl] mono [3-(hexadecyloxy) propyl] ester) is a lipid conjugate of the acyclic …

CMX001, a lipophilic nucleotide analog formed by covalently linking 3-(hexdecyloxy) propan-
1-ol to cidofovir (CDV), is being developed as a treatment for smallpox. CMX001 has …

Hexadecyloxypropyl-cidofovir (HDP-CDV) is a novel ether lipid conjugate of (S)-1-(3-
hydroxy-2-phosphonoylmethoxypropyl)-cytosine (CDV) which exhibits a remarkable …

In the 21st century we are faced with the potential use of natural or recombinant VARV and
MPXV as biological weapons, and the emergence of human MPXV. Such an occurrences …

CMX001, a lipophilic nucleotide analog formed by covalently linking 3-(hexdecyloxy) propan-
1-ol to cidofovir (CDV), is being developed as a treatment for smallpox. In the absence of …

Cidofovir [(S)-1-(3-hydroxy-2-phosphonylmethoxypropyl) cytosine, HPMPC] is an acyclic
nucleoside analog approved since 1996 for clinical use in the treatment of cytomegalovirus …

ABSTRACT CMX001 is an orally available lipid acyclic nucleotide phosphonate that delivers
high intracellular levels of cidofovir (CDV)-diphosphate and exhibits enhanced in vitro …

Although it is often stated that only vaccination would be able to contain or protect the
population against a catastrophic smallpox outbreak, the acyclic nucleoside phosphonate …

Surrogate animal models must be used for testing antiviral agents against variola (smallpox)
virus infections. Once developed, these compounds can be stockpiled for use in the event of …

Cidofovir (CDV) is a highly effective inhibitor of orthopoxvirus replication and may be used
intravenously to treat smallpox or complications arising from the smallpox vaccine under an …