Simple Summary The desire to reduce the use of animals in research and drug testing has
led to an upsurge in the development of 3-Dimensional models, which try and mimic parts of …

Predicting individual radiotherapy (RT) response is valuable in managing head and neck
squamous cell carcinoma (HNSCC). We assessed the feasibility of our novel 3D culture …

Radiotherapy is the standard treatment for head and neck squamous cell carcinoma
(HNSCC), however, radioresistance remains a major clinical problem despite significant …

Current treatment options for advanced and recurrent head and neck squamous cell
carcinoma (HNSCC) enclose radiation and chemo-radiation approaches with or without …

Abstract Development of personalised cancer models to predict response to radiation would
benefit patient care; particularly in malignancies where treatment resistance is prevalent …

Cancer-associated fibroblasts (CAFs) are a key component of the tumour microenvironment
and have been shown to play an important role in the progression of cancer. To probe these …

Background: Head and neck squamous cell carcinomas (HNSCC) are phenotypically and
molecularly heterogeneous and frequently develop therapy resistance. Reliable patient …

Materials and Methods Surgical resection material of oral cavity HNSCC tumors has been
cut into 300 um slices and cultured in a medium that maintained proliferation of tumor cells …

Head and neck squamous cell carcinoma (HNSCC) is characterized by a poor 5 year
survival and varying response rates to both standard-of-care and new treatments. Despite …

With the development of various radiation-based cancer therapies, radiobiological
evaluation methods instead of traditional clonogenic assays with monolayer single cell …