Head and Neck Squamous Cell Carcinoma Biopsies Maintained Ex Vivo on a Perfusion Device Show Gene Changes with Time and Clinically Relevant Doses of …
V Green, L Baldwin, J England, G Marshall, L Frost… - Cancers, 2023 - mdpi.com
Simple Summary The desire to reduce the use of animals in research and drug testing has
led to an upsurge in the development of 3-Dimensional models, which try and mimic parts of …
led to an upsurge in the development of 3-Dimensional models, which try and mimic parts of …
[HTML][HTML] A novel 3D pillar/well array platform using patient-derived head and neck tumor to predict the individual radioresponse
DW Lee, SY Choi, SY Kim, HJ Kim, DY Shin… - Translational …, 2022 - Elsevier
Predicting individual radiotherapy (RT) response is valuable in managing head and neck
squamous cell carcinoma (HNSCC). We assessed the feasibility of our novel 3D culture …
squamous cell carcinoma (HNSCC). We assessed the feasibility of our novel 3D culture …
Measuring the response of human head and neck squamous cell carcinoma to irradiation in a microfluidic model allowing customized therapy
R Cheah, R Srivastava… - International …, 2017 - spandidos-publications.com
Radiotherapy is the standard treatment for head and neck squamous cell carcinoma
(HNSCC), however, radioresistance remains a major clinical problem despite significant …
(HNSCC), however, radioresistance remains a major clinical problem despite significant …
[HTML][HTML] Therapy testing in a spheroid-based 3D cell culture model for head and neck squamous cell carcinoma
J Hagemann, C Jacobi, S Gstoettner… - Journal of visualized …, 2018 - ncbi.nlm.nih.gov
Current treatment options for advanced and recurrent head and neck squamous cell
carcinoma (HNSCC) enclose radiation and chemo-radiation approaches with or without …
carcinoma (HNSCC) enclose radiation and chemo-radiation approaches with or without …
A patient tumour-on-a-chip system for personalised investigation of radiotherapy based treatment regimens
R Kennedy, D Kuvshinov, A Sdrolia, E Kuvshinova… - Scientific Reports, 2019 - nature.com
Abstract Development of personalised cancer models to predict response to radiation would
benefit patient care; particularly in malignancies where treatment resistance is prevalent …
benefit patient care; particularly in malignancies where treatment resistance is prevalent …
A TRACER 3D Co-Culture tumour model for head and neck cancer
M Young, D Rodenhizer, T Dean, E D'Arcangelo, B Xu… - Biomaterials, 2018 - Elsevier
Cancer-associated fibroblasts (CAFs) are a key component of the tumour microenvironment
and have been shown to play an important role in the progression of cancer. To probe these …
and have been shown to play an important role in the progression of cancer. To probe these …
Organotypic co-cultures as a novel 3D model for head and neck squamous cell carcinoma
L Engelmann, J Thierauf, N Koerich Laureano… - Cancers, 2020 - mdpi.com
Background: Head and neck squamous cell carcinomas (HNSCC) are phenotypically and
molecularly heterogeneous and frequently develop therapy resistance. Reliable patient …
molecularly heterogeneous and frequently develop therapy resistance. Reliable patient …
Ex vivo functional assay for predicting radiation treatment response in squamous cell carcinoma of the head and neck
ME Capala, GM Verduijn, SF Petit, MA de Korte… - Oral Oncology, 2021 - Elsevier
Materials and Methods Surgical resection material of oral cavity HNSCC tumors has been
cut into 300 um slices and cultured in a medium that maintained proliferation of tumor cells …
cut into 300 um slices and cultured in a medium that maintained proliferation of tumor cells …
Ex vivo culture models to indicate therapy response in head and neck squamous cell carcinoma
I Demers, J Donkers, B Kremer, EJ Speel - Cells, 2020 - mdpi.com
Head and neck squamous cell carcinoma (HNSCC) is characterized by a poor 5 year
survival and varying response rates to both standard-of-care and new treatments. Despite …
survival and varying response rates to both standard-of-care and new treatments. Despite …
[HTML][HTML] Radiation evaluation assay using a human three-dimensional oral cancer model for clinical radiation therapy.
L Sercombe, K Igawa, K Izumi - Talanta Open, 2024 - Elsevier
With the development of various radiation-based cancer therapies, radiobiological
evaluation methods instead of traditional clonogenic assays with monolayer single cell …
evaluation methods instead of traditional clonogenic assays with monolayer single cell …