Calcitonin gene-related peptide but not substance P mimics capsaicin-induced coronary vasodilation in the pig

A Franco-Cereceda, A Rudehill… - European journal of …, 1987 - Elsevier
The vasodilator effects of the human calcitonin gene-related peptides α (hCGRPα) and β
(hCGRPβ) were studied in vitro and in vivo in relation to the effects of substance P (SP) and …

Capsaicin‐induced vasodilatation of human coronary arteries in vitro is mediated by calcitonin gene‐related peptide rather than substance P or neurokinin A

A Franco‐Cereceda, A Rudehill - Acta physiologica …, 1989 - Wiley Online Library
In the present study the possible influence of capsaicin on human arterial coronary tone in
vitro was studied in relation to the vasodilatory properties of calcitonin gene‐related peptide …

Potential of calcitonin gene-related peptide in coronary heart disease

A Franco-Cereceda, J Liska - Pharmacology, 2000 - karger.com
A subpopulation of capsaicin-sensitive cardiac C-fibre afferents co-store calcitonin gene-
related peptide (CGRP), substance P and neurokinin A. CGRP exerts positive inotropic and …

Calcitonin gene‐related peptide and human epicardial coronary arteries: presence, release and vasodilator effects

A Franco‐Cereceda - British journal of pharmacology, 1991 - Wiley Online Library
1 In the present study, the levels of calcitonin gene‐related peptide (CGRP)‐like
immunoreactivity (‐LI) in human cardiopulmonary tissue were determined in combination …

Heterogeneous involvement of endothelium in calcitonin gene-related peptide-induced relaxation in coronary arteries from rat.

D Prieto, S Benedito, NC Nyborg - British journal of pharmacology, 1991 - ncbi.nlm.nih.gov
The effects of rat-and human-CGRP and capsaicin were studied in isolated rings of rat
proximal epicardial (PC) and distal intramyocardial (DC) coronary arteries. 2. The relaxing …

Vasodilating effects of human and rat calcitonin gene-related peptides in isolated porcine coronary arteries

T Shoji, I Ishihara, T Ishikawa, A Saito… - … Schmiedeberg's archives of …, 1987 - Springer
Human and rat α-calcitonin gene-related peptides (CGRPs) caused relaxation of porcine
coronary arterial strips precontracted by 10− 5 M of prostaglandin (PG) F 2α at low …

Effects of substance P, calcitonin gene-related peptide and capsaicin on tension and membrane potential of pig coronary artery in vitro

JL Bény, PC Brunet, H Huggel - Regulatory peptides, 1989 - Elsevier
The effects of substance P (SP), calcitonin gene-related peptide (CGRP) and capsaicin were
studied on isometric tension and membrane potential of pig coronary arterial strips in vitro …

Calcitonin gene-related peptide and tachykinins in relation to local sensory control of cardiac contractility and coronary vascular tone.

A Franco-Cereceda - Acta physiologica Scandinavica …, 1988 - europepmc.org
The possible role of peptides locally released from sensory nerves in the control of cardiac
contractility and the coronary vascular tone was investigated in the present study …

Mechanism of action of human calcitonin gene-related peptide in rabbit heart and in human mammary arteries

R Raddino, G Pela, C Manca… - Journal of …, 1997 - journals.lww.com
We investigated the effects of human calcitonin gene-related peptide (CGRP) on isolated
rabbit hearts to evaluate the mechanisms responsible for the vasodilatory action of the …

Aggravation of myocardial infarction in the porcine heart by capsaicin-induced depletion of calcitonin gene-related peptide (CGRP)

G Källner, A Franco-Cereceda - Journal of cardiovascular …, 1998 - journals.lww.com
The potent vasodilator calcitonin gene-related peptide (CGRP) is stored in a population of C-
fiber afferents that are sensitive to capsaicin. CGRP has been suggested to have a …