Pathogen blockade of TAK1 triggers caspase-8–dependent cleavage of gasdermin D and cell death
Limited proteolysis of gasdermin D (GSDMD) generates an N-terminal pore-forming
fragment that controls pyroptosis in macrophages. GSDMD is processed via inflammasome …
fragment that controls pyroptosis in macrophages. GSDMD is processed via inflammasome …
[PDF][PDF] Control of gasdermin D oligomerization and pyroptosis by the Ragulator-Rag-mTORC1 pathway
CL Evavold, I Hafner-Bratkovič, P Devant, JM D'Andrea… - Cell, 2021 - cell.com
The process of pyroptosis is mediated by inflammasomes and a downstream effector known
as gasdermin D (GSDMD). Upon cleavage by inflammasome-associated caspases, the N …
as gasdermin D (GSDMD). Upon cleavage by inflammasome-associated caspases, the N …
Caspase-8–dependent gasdermin D cleavage promotes antimicrobial defense but confers susceptibility to TNF-induced lethality
B Demarco, JP Grayczyk, E Bjanes, D Le Roy… - Science …, 2020 - science.org
Gasdermin D (GSDMD) is a pore-forming protein that promotes pyroptosis and release of
proinflammatory cytokines. Recent studies revealed that apoptotic caspase-8 directly …
proinflammatory cytokines. Recent studies revealed that apoptotic caspase-8 directly …
Mechanism and regulation of gasdermin-mediated cell death
The innate immune system senses and responds to pathogens and endogenous damage
through supramolecular protein complexes known as inflammasomes. Cytosolic …
through supramolecular protein complexes known as inflammasomes. Cytosolic …
[PDF][PDF] Gasdermin E permits interleukin-1 beta release in distinct sublytic and pyroptotic phases
Cellular inflammasome activation causes caspase-1 cleavage of the pore-forming protein
gasdermin D (GSDMD) with subsequent pyroptotic cell death and cytokine release. Here …
gasdermin D (GSDMD) with subsequent pyroptotic cell death and cytokine release. Here …
Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores
Abstract Inflammatory caspases (caspases 1, 4, 5 and 11) are activated in response to
microbial infection and danger signals. When activated, they cleave mouse and human …
microbial infection and danger signals. When activated, they cleave mouse and human …
Gasdermin D pore structure reveals preferential release of mature interleukin-1
As organelles of the innate immune system, inflammasomes activate caspase-1 and other
inflammatory caspases that cleave gasdermin D (GSDMD). Caspase-1 also cleaves inactive …
inflammatory caspases that cleave gasdermin D (GSDMD). Caspase-1 also cleaves inactive …
Caspase-1 initiates apoptosis in the absence of gasdermin D
K Tsuchiya, S Nakajima, S Hosojima… - Nature …, 2019 - nature.com
Caspase-1 activated in inflammasomes triggers a programmed necrosis called pyroptosis,
which is mediated by gasdermin D (GSDMD). However, GSDMD-deficient cells are still …
which is mediated by gasdermin D (GSDMD). However, GSDMD-deficient cells are still …
Mechanism of gasdermin D recognition by inflammatory caspases and their inhibition by a gasdermin D-derived peptide inhibitor
The inflammasomes are signaling platforms that promote the activation of inflammatory
caspases such as caspases-1,-4,-5, and-11. Recent studies identified gasdermin D …
caspases such as caspases-1,-4,-5, and-11. Recent studies identified gasdermin D …
[PDF][PDF] Crystal structures of the full-length murine and human gasdermin D reveal mechanisms of autoinhibition, lipid binding, and oligomerization
Gasdermin D (GSDMD) is an effector molecule for pyroptosis downstream of canonical and
noncanonical inflammasome signaling pathways. Cleavage of GSDMD by inflammatory …
noncanonical inflammasome signaling pathways. Cleavage of GSDMD by inflammatory …