Endogenous melatonin is synthesized from tryptophan via 5-hydroxytryptamine. It is
considered an indoleamine from a biochemical point of view because the melatonin …

Melatonin (N-acetyl-5-methoxytryptamine) was first purified and characterized from the
bovine pineal gland extract by Aron Lerner and co-workers in 1958. Since then, a plethora of …

Melatonin is ubiquitous molecule with wide distribution in nature and is produced by many
living organisms. In human beings, pineal gland is the major site for melatonin production …

Melatonin is a hormone produced mainly by the pineal gland in most vertebrate species,
including humans. Recent metabolic, receptor and functional studies created a picture of the …

Melatonin is a hormone secreted from the pineal gland specifically at night and contributes
to a wide array of physiological functions in mammals. Melatonin is one of the most well …

Much attention has been recently drawn to studying melatonin–a hormone whose synthesis
was first found in the epiphysis (pineal gland). This interest can be due to discovering the …

Melatonin is a ubiquitous molecule and widely distributed in nature, with functional activity
occurring in unicellular organisms, plants, fungi and animals. In most vertebrates, including …

Melatonin is an evolutionarily conserved molecule that serves a time-keeping function in
various species. In vertebrates, melatonin is produced predominantly by the pineal gland …

Melatonin is a ubiquitous molecule present in almost every live being from bacteria to
humans. In vertebrates, besides being produced in peripheral tissues and acting as an …

It has been historically assumed that the pineal gland is the major source of melatonin (N‐
acetyl‐5‐methoxytryptamine) in vertebrates. Melatonin plays a central role in fine‐tuning …