Different T cell receptor affinity thresholds and CD8 coreceptor dependence govern cytotoxic T lymphocyte activation and tetramer binding properties
T cells have evolved a unique system of ligand recognition involving an antigen T cell
receptor (TCR) and a coreceptor that integrate stimuli provided by the engagement of …
receptor (TCR) and a coreceptor that integrate stimuli provided by the engagement of …
Interaction between the CD8 coreceptor and major histocompatibility complex class I stabilizes T cell receptor-antigen complexes at the cell surface
L Wooldridge, HA van den Berg, M Glick… - Journal of Biological …, 2005 - ASBMB
The off-rate (k off) of the T cell receptor (TCR)/peptide-major histocompatibility complex class
I (pMHCI) interaction, and hence its half-life, is the principal kinetic feature that determines …
I (pMHCI) interaction, and hence its half-life, is the principal kinetic feature that determines …
T-cell receptor (TCR)-peptide specificity overrides affinity-enhancing TCR-major histocompatibility complex interactions
DK Cole, KM Miles, F Madura, CJ Holland… - Journal of Biological …, 2014 - ASBMB
αβ T-cell receptors (TCRs) engage antigens using complementarity-determining region
(CDR) loops that are either germ line-encoded (CDR1 and CDR2) or somatically rearranged …
(CDR) loops that are either germ line-encoded (CDR1 and CDR2) or somatically rearranged …
T‐cell receptor binding affinities and kinetics: impact on T‐cell activity and specificity
The interaction between the T‐cell receptor (TCR) and its peptide–major histocompatibility
complex (pepMHC) ligand plays a critical role in determining the activity and specificity of …
complex (pepMHC) ligand plays a critical role in determining the activity and specificity of …
Critical role for CD8 in T cell receptor binding and activation by peptide/major histocompatibility complex multimers
MA Daniels, SC Jameson - The Journal of experimental medicine, 2000 - rupress.org
Recent data using MHC/peptide tetramers and dimers suggests that the T cell coreceptors,
CD4 and CD8, although important for T cell activation, do not play a direct role in facilitating …
CD4 and CD8, although important for T cell activation, do not play a direct role in facilitating …
Two-stage cooperative T cell receptor-peptide major histocompatibility complex-CD8 trimolecular interactions amplify antigen discrimination
The T cell receptor (TCR) and CD8 bind peptide-major histocompatibility complex (pMHC)
glycoproteins to initiate adaptive immune responses, yet the trimolecular binding kinetics at …
glycoproteins to initiate adaptive immune responses, yet the trimolecular binding kinetics at …
Cooperative binding of T cell receptor and CD4 to peptide-MHC enhances antigen sensitivity
Antigen recognition by the T cell receptor (TCR) of CD4+ T cells can be greatly enhanced by
the coreceptor CD4. Yet, understanding of the molecular mechanism is hindered by the ultra …
the coreceptor CD4. Yet, understanding of the molecular mechanism is hindered by the ultra …
The efficiency of CD4 recruitment to ligand-engaged TCR controls the agonist/partial agonist properties of peptide–MHC molecule ligands
J Madrenas, LA Chau, J Smith, JA Bluestone… - The Journal of …, 1997 - rupress.org
One hypothesis seeking to explain the signaling and biological properties of T cell receptor
for antigen (TCR) partial agonists and antagonists is the coreceptor density/kinetic model …
for antigen (TCR) partial agonists and antagonists is the coreceptor density/kinetic model …
[HTML][HTML] Altered peptide ligands induce delayed CD8-T cell receptor interaction—a role for CD8 in distinguishing antigen quality
PP Yachi, J Ampudia, T Zal, NRJ Gascoigne - Immunity, 2006 - cell.com
How T cells translate T cell receptor (TCR) recognition of almost identical pMHC ligands into
distinct biological responses has remained enigmatic. Although differences in affinity or off …
distinct biological responses has remained enigmatic. Although differences in affinity or off …
T cell receptor engagement by peptide–MHC ligands induces a conformational change in the CD3 complex of thymocytes
The T cell receptor (TCR) can recognize a variety of cognate peptide/major
histocompatibility complex (pMHC) ligands and translate their affinity into distinct cellular …
histocompatibility complex (pMHC) ligands and translate their affinity into distinct cellular …