Thyroid hormone (TH) is critical for the maintenance of cellular homeostasis during stress
responses, but its role in lung fibrosis is unknown. Here we found that the activity and …

Idiopathic pulmonary fibrosis (IPF) is a progressive fatal interstitial lung disease without an
effective cure. Herein, we explore the role of 3, 5, 3′-triiodothyronine (T3) administration on …

Chronic obstructive pulmonary disease (COPD) is linked to both cigarette smoking and
genetic determinants. We have previously identified iron-responsive element–binding …

Osteoclasts are acid-secreting polykaryons that have high energy demands and contain
abundant mitochondria. How mitochondrial biogenesis is integrated with osteoclast …

Aging is a risk factor for progressive fibrotic disorders involving diverse organ systems,
including the lung. Idiopathic pulmonary fibrosis, an age-associated degenerative lung …

Rtp801 (also known as Redd1, and encoded by Ddit4), a stress-related protein triggered by
adverse environmental conditions, inhibits mammalian target of rapamycin (mTOR) by …

Accumulating evidence illustrates a fundamental role for mitochondria in lung alveolar type
2 epithelial cell (AEC2) dysfunction in the pathogenesis of idiopathic pulmonary fibrosis …

Asthma is a disease of acute and chronic inflammation in which cytokines play a critical role
in orchestrating the allergic inflammatory response. IL-13 and transforming growth factor …

Idiopathic pulmonary fibrosis is characterized by excessive deposition of collagen in the
lung, leading to chronically impaired gas exchange and death,–. Oxidative stress is believed …

Mitochondria are involved in a variety of cellular functions, including ATP production, amino
acid and lipid biogenesis and breakdown, signalling and apoptosis,,. Mitochondrial …