The functional state of T cells is a key determinant for effective antitumor immunity and
immunotherapy. Cellular metabolism, including lipid metabolism, controls T cell …

Effector, memory and exhaustion are three phenotypes of CD8+ T cell. In tumor
microenvironment (TME), metabolism dysfunction of the three should take the blame for …

Metabolic reprogramming is one of the most important hallmarks of malignant tumors.
Specifically, lipid metabolic reprogramming has marked impacts on cancer progression and …

CD8+ T cell longevity regulated by metabolic activity plays important roles in cancer
immunotherapy. Although in vitro–polarized, transferred IL-9–secreting CD8+ Tc9 (cytotoxic …

Lipid metabolic reprogramming is an emerging hallmark of cancer. In order to sustain
uncontrolled proliferation and survive in unfavorable environments that lack oxygen and …

Myeloid-derived suppressor cells (MDSCs) play crucial roles in tumorigenesis and their
inhibition is critical for successful cancer immunotherapy. MDSCs undergo metabolic …

The tumormicroenvironment (TME) plays a key role in tumor progression. Tumor-associated
macrophages (TAMs), which are natural immune cells abundantin the TME, are mainly …

Dysregulated lipid metabolism represents an important metabolic alteration in cancer. Fatty
acids, cholesterol, and phospholipid are the three most prevalent lipids that act as energy …

Cancer progression generates a chronic inflammatory state that dramatically influences
hematopoiesis, originating different subsets of immune cells that can exert pro-or anti-tumor …

Myeloid-derived suppressor cells (MDSC) promote tumor growth by blocking anti-tumor T
cell responses. Recent reports show that MDSC increase fatty acid uptake and fatty acid …