Senescence and altered differentiation potential of bone marrow stromal cells (BMSCs) lead
to age‐related bone loss. As an important posttranscriptional regulatory pathway, alternative …

Histone modifications critically contribute to the epigenetic orchestration of bone
homeostasis—in part, by modifying the access of transcription factors to specific genes …

A hallmark of aged mesenchymal stem/progenitor cells (MSCs) in bone marrow is the pivot
of differentiation potency from osteoblast to adipocyte coupled with a decrease in self …

Cellular plasticity is a key facet of cellular homeostasis requiring correct temporal and spatial
patterns of alternative splicing. Splicing factors, which orchestrate this process, demonstrate …

Skeletal stem and progenitor cells (SSPCs) perform bone maintenance and repair. With age,
they produce fewer osteoblasts and more adipocytes leading to a loss of skeletal integrity …

Senescence of bone marrow mesenchymal stem cells (BMSCs) impairs stemness and
osteogenic differentiation, but the key regulators for senescence and the related …

SOX2 is crucial for the maintenance of the self-renewal capacity and multipotency of
mesenchymal stem cells (MSCs); however, the mechanism by which SOX2 is regulated …

Abstract Stromal cell-derived factor-1 (SDF-1 or CXCL12) is a cytokine secreted by cells
including bone marrow stromal cells (BMSCs). SDF-1 plays a vital role in BMSC migration …

Ubiquitin ligase Smurf1‐deficient mice develop an increased‐bone‐mass phenotype in an
age‐dependent manner. It was reported that such a bone‐mass increase is related to …

Postmenopausal osteoporosis (PMOP) is a common systemic skeletal disease
characterized by reduced bone mass and microarchitecture deterioration. Although …