Head and neck squamous cell carcinoma (HNSCC) is an extremely aggressive cancer with
a poor prognosis and low patient survival. Because chemotherapy for advanced HNSCC is …

TGF-β1 is a multifunctional cytokine that mediates diverse biological processes. However,
the mechanisms by which the intracellular signals of TGF-β1 are terminated are not well …

Despite favorable responses to initial chemotherapy, drug resistance is a major cause
limiting chemotherapeutic efficacy in many advanced cancers. However, mechanisms that …

Background: Cyclooxygenase-2 (COX-2) is over-expressed in colorectal cancer (CRC),
rendering tumour cells resistant to apoptosis. Selective COX-2 inhibition is effective in CRC …

Drak2 is a death-associated protein family serine-threonine kinase. Its expression and roles
in the immune system were investigated in this study. According to in situ hybridization …

The adaptor protein TNF receptor-associated factor 6 (TRAF6) is a key mediator in
inflammation. However, the molecular mechanisms controlling its activity and stability in …

DAP kinase-related apoptosis-inducing kinase 2 (DRAK2), a member of the DAP kinase
family, is a serine/threonine kinase capable of inducing apoptosis. Here we studied the …

N-myc downstream-regulated gene 1 (NDRG1) has been implicated in tumorigenesis and
metastasis in different cancers. However, its role in nasopharyngeal carcinoma remains …

Transforming growth factor-beta (TGFβ) is a secreted polypeptide that plays essential roles
in cellular development and homeostasis. Although mechanisms of TGFβ-induced …

Gastric cancer (GC) represents the fourth most common malignant neoplasm and the
second leading cause of cancer death. Despite therapeutic advances in recent decades, the …