Interpretable machine learning reveals a diverse arsenal of anti-defenses in bacterial viruses
A Lopatina, M Ferenc, N Bartlau, M Wolfram… - bioRxiv, 2024 - biorxiv.org
Antagonistic interactions with viruses are an important driver of the ecology and evolution of
bacteria, and associating genetic signatures to these interactions is of fundamental …
bacteria, and associating genetic signatures to these interactions is of fundamental …
Interpretable machine learning reveals a diverse arsenal of anti-defenses in 1 bacterial viruses
M Polz, A Lopatina, M Ferenc, N Bartlau, M Wolfram… - 2024 - researchsquare.com
Antagonistic interactions with viruses are an important driver of the ecology and evolution of
bacteria, and associating genetic signatures to these interactions is of fundamental …
bacteria, and associating genetic signatures to these interactions is of fundamental …
Bacterial defenses and their trade-off with growth are not ubiquitous but depend on ecological contexts
ZL Liu, J Liu, DK Niu - bioRxiv, 2024 - biorxiv.org
Bacteriophages, also known as bacterial viruses, exert significant influence on microbial
ecosystems due to their widespread presence. In response to the threat of phage predation …
ecosystems due to their widespread presence. In response to the threat of phage predation …
New antiviral defences are genetically embedded within prokaryotic immune systems.
Bacteria and archaea typically have multiple defence systems that protect them against viral
predation. Recently, many new defence systems have been discovered, yet the full scope of …
predation. Recently, many new defence systems have been discovered, yet the full scope of …
High defense system expression broadens protection range at the cost of increased autoimmunity
N Aframian, S Omer-Bendori, T Hen, P Guler, A Eldar - bioRxiv, 2023 - biorxiv.org
The evolutionary arms race between bacteria and their phage viruses has given rise to
elaborate anti-phage defense mechanisms. Major advances have been made in revealing …
elaborate anti-phage defense mechanisms. Major advances have been made in revealing …
[HTML][HTML] Fossicking for microbial defense system: novel antiviral immunity
P Lin, Q Wu, M Wu - Signal Transduction and Targeted Therapy, 2020 - nature.com
A recent paper in Science by Gao et al. extended a comprehensive comparative genomics
approach to identify new antiviral systems in prokaryotes for combating invading phages. 1 …
approach to identify new antiviral systems in prokaryotes for combating invading phages. 1 …
Mapping the landscape of anti-phage defense mechanisms in the E. coli pangenome
C Vassallo, C Doering, ML Littlehale, G Teodoro… - BioRxiv, 2022 - biorxiv.org
The ancient, ongoing coevolutionary battle between bacteria and their viral predators,
bacteriophages, has given rise to sophisticated immune systems including restriction …
bacteriophages, has given rise to sophisticated immune systems including restriction …
[HTML][HTML] Systematic and quantitative view of the antiviral arsenal of prokaryotes
Bacteria and archaea have developed multiple antiviral mechanisms, and genomic
evidence indicates that several of these antiviral systems co-occur in the same strain. Here …
evidence indicates that several of these antiviral systems co-occur in the same strain. Here …
Rapid evolutionary turnover of mobile genetic elements drives microbial resistance to viruses
Although it is generally accepted that viruses (phages) drive bacterial evolution, how these
dynamics play out in the wild remains poorly understood. Here we show that the arms race …
dynamics play out in the wild remains poorly understood. Here we show that the arms race …
Comparative transcriptomics reveals a conserved Bacterial Adaptive Phage Response (BAPR) to viral predation
Intrinsic and acquired defenses against bacteriophages, including Restriction/Modification,
CRISPR/Cas, and Toxin/Anti-toxin systems have been intensely studied, with profound …
CRISPR/Cas, and Toxin/Anti-toxin systems have been intensely studied, with profound …