Interpretable machine learning reveals a diverse arsenal of anti-defenses in bacterial viruses

A Lopatina, M Ferenc, N Bartlau, M Wolfram… - bioRxiv, 2024 - biorxiv.org
Antagonistic interactions with viruses are an important driver of the ecology and evolution of
bacteria, and associating genetic signatures to these interactions is of fundamental …

Interpretable machine learning reveals a diverse arsenal of anti-defenses in 1 bacterial viruses

M Polz, A Lopatina, M Ferenc, N Bartlau, M Wolfram… - 2024 - researchsquare.com
Antagonistic interactions with viruses are an important driver of the ecology and evolution of
bacteria, and associating genetic signatures to these interactions is of fundamental …

Bacterial defenses and their trade-off with growth are not ubiquitous but depend on ecological contexts

ZL Liu, J Liu, DK Niu - bioRxiv, 2024 - biorxiv.org
Bacteriophages, also known as bacterial viruses, exert significant influence on microbial
ecosystems due to their widespread presence. In response to the threat of phage predation …

New antiviral defences are genetically embedded within prokaryotic immune systems.

LJ Payne, TCD Hughes, PC Fineran, SA Jackson - bioRxiv, 2024 - biorxiv.org
Bacteria and archaea typically have multiple defence systems that protect them against viral
predation. Recently, many new defence systems have been discovered, yet the full scope of …

High defense system expression broadens protection range at the cost of increased autoimmunity

N Aframian, S Omer-Bendori, T Hen, P Guler, A Eldar - bioRxiv, 2023 - biorxiv.org
The evolutionary arms race between bacteria and their phage viruses has given rise to
elaborate anti-phage defense mechanisms. Major advances have been made in revealing …

[HTML][HTML] Fossicking for microbial defense system: novel antiviral immunity

P Lin, Q Wu, M Wu - Signal Transduction and Targeted Therapy, 2020 - nature.com
A recent paper in Science by Gao et al. extended a comprehensive comparative genomics
approach to identify new antiviral systems in prokaryotes for combating invading phages. 1 …

Mapping the landscape of anti-phage defense mechanisms in the E. coli pangenome

C Vassallo, C Doering, ML Littlehale, G Teodoro… - BioRxiv, 2022 - biorxiv.org
The ancient, ongoing coevolutionary battle between bacteria and their viral predators,
bacteriophages, has given rise to sophisticated immune systems including restriction …

[HTML][HTML] Systematic and quantitative view of the antiviral arsenal of prokaryotes

F Tesson, A Hervé, E Mordret, M Touchon… - Nature …, 2022 - nature.com
Bacteria and archaea have developed multiple antiviral mechanisms, and genomic
evidence indicates that several of these antiviral systems co-occur in the same strain. Here …

Rapid evolutionary turnover of mobile genetic elements drives microbial resistance to viruses

FA Hussain, J Dubert, J Elsherbini, M Murphy… - Biorxiv, 2021 - biorxiv.org
Although it is generally accepted that viruses (phages) drive bacterial evolution, how these
dynamics play out in the wild remains poorly understood. Here we show that the arms race …

Comparative transcriptomics reveals a conserved Bacterial Adaptive Phage Response (BAPR) to viral predation

BG Blasdel, PJ Ceyssens, A Chevallereau… - BioRxiv, 2018 - biorxiv.org
Intrinsic and acquired defenses against bacteriophages, including Restriction/Modification,
CRISPR/Cas, and Toxin/Anti-toxin systems have been intensely studied, with profound …