UCL 16:9 PP Plain - MID RED Page 1 Mathematical Modelling of CD19+ B Cell
Reconstitution in Children After Insult to the Immune System PAGE Lewis Sheiner Student …

OBJECTIVE: Functional recovery of B lymphocytes after hematopoietic stem cell
transplantation (HSCT) can take up to 2 years. HSCT recipients may obtain protective titers …

Severe combined immunodeficiencies (SCIDs) correspond to the most severe form of
primary immunodeficiency. Allogeneic hematopoietic stem cell transplantation (HSCT) and …

Reduced total and memory B-cell numbers in peripheral blood long term after hematopoietic
stem cell transplantation (HSCT) are associated with an increased incidence of infections …

Work in the past years has led to a refined phenotypical description of functionally distinct T-
and B-cell subsets. Since both lymphocyte compartments are established and undergo …

The composition of the peripheral blood lymphocyte compartment underlies developmental
changes during ontogeny. Recently, several new B cell populations have been …

Mechanistic mathematical modelling can be used to understand the fundamental drivers of
the immune system and how the system is affected by medical interventions. Key to this …

Mathematical models, combined with experimental data, have provided several important
insights into the mechanisms and dynamics of CD4 T cell homeostasis in development …

B cells produce antibodies that are indispensable for host defence against infections,
through virus neutralization, opsonization of pathogens for efficient phagocytosis by …

Neonates are particularly susceptible to a number of infections, and the neonatal CD8+ T‐
cell response demonstrates differences in both the phenotype and magnitude of responses …