[HTML][HTML] Multifaceted superoxide dismutase 1 expression in amyotrophic lateral sclerosis patients: a rare occurrence?

I Martinelli, J Mandrioli, A Ghezzi, E Zucchi… - Neural Regeneration …, 2025 - journals.lww.com
Amyotrophic lateral sclerosis (ALS) is a neuromuscular condition resulting from the
progressive degeneration of motor neurons in the cortex, brainstem, and spinal cord. While …

[HTML][HTML] Rapid progression of sporadic als in a patient carrying sod1 p. Gly13arg mutation

MJ Kim, JH Bae, JM Kim, HR Kim, BN Yoon… - Experimental …, 2016 - ncbi.nlm.nih.gov
Amyotrophic lateral sclerosis (ALS), the most common adult onset motor neuron disease, is
pathologically characterized by progressive loss of the upper and lower motor neurons …

[HTML][HTML] Insights on the Multifaceted Roles of Wild-Type and Mutated Superoxide Dismutase 1 in Amyotrophic Lateral Sclerosis Pathogenesis

V Rubino, G La Rosa, L Pipicelli, F Carriero… - Antioxidants, 2023 - mdpi.com
Amyotrophic Lateral Sclerosis (ALS) is a progressive motor neurodegenerative disease. Cell
damage in ALS is the result of many different, largely unknown, pathogenetic mechanisms …

[HTML][HTML] Does wild-type Cu/Zn-superoxide dismutase have pathogenic roles in amyotrophic lateral sclerosis?

Y Furukawa, E Tokuda - Translational Neurodegeneration, 2020 - Springer
Amyotrophic lateral sclerosis (ALS) is characterized by adult-onset progressive
degeneration of upper and lower motor neurons. Increasing numbers of genes are found to …

[HTML][HTML] Skeletal muscle-restricted expression of human SOD1 in transgenic mice causes a fatal ALS-like syndrome

LJ Martin, M Wong - Frontiers in Neurology, 2020 - frontiersin.org
Amyotrophic lateral sclerosis (ALS) is a fatal heterogeneous neurodegenerative disease that
causes motor neuron (MN) loss and skeletal muscle paralysis. It is uncertain whether this …

[HTML][HTML] A Novel Variant in Superoxide Dismutase 1 Gene (p.V119M) in Als Patients with Pure Lower Motor Neuron Presentation

C Ricci, F Giannini, G Riolo, S Bocci, S Casali… - Genes, 2021 - mdpi.com
Amyotrophic lateral sclerosis (ALS) is a progressive and fatal disorder characterized by
degeneration of motor neurons in the cerebral cortex, brain stem, and spinal cord. Most …

[HTML][HTML] The role of superoxide dismutase 1 in amyotrophic lateral sclerosis: identification of signaling pathways, regulators, molecular interaction networks, and …

SK Suthar, SY Lee - Brain Sciences, 2023 - mdpi.com
Mutations in superoxide dismutase 1 (SOD1) result in misfolding and aggregation of the
protein, causing neurodegenerative amyotrophic lateral sclerosis (ALS). In recent years …

Amyotrophic lateral sclerosis associated with mutations in superoxide dismutase: a putative mechanism of degeneration

BM Morrison, JH Morrison - Brain research reviews, 1999 - Elsevier
Amyotrophic lateral sclerosis (ALS) is a devastating neurologic disease that rapidly
progresses from mild motor symptoms to severe motor paralysis and premature death. Until …

Amyotrophic lateral sclerosis: pathogenesis

RH Brown Jr, W Robberecht - Seminars in neurology, 2001 - thieme-connect.com
Amyotrophic lateral sclerosis (ALS) is a devastating paralytic disorder caused by motor
neuron degeneration. A subgroup of familial cases arises from mutations in the gene …

[HTML][HTML] SOD1 in ALS: taking stock in pathogenic mechanisms and the role of glial and muscle cells

C Peggion, V Scalcon, ML Massimino, K Nies… - Antioxidants, 2022 - mdpi.com
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by
the loss of motor neurons in the brain and spinal cord. While the exact causes of ALS are still …