[HTML][HTML] Defining HLA-II ligand processing and binding rules with mass spectrometry enhances cancer epitope prediction
Increasing evidence indicates CD4+ T cells can recognize cancer-specific antigens and
control tumor growth. However, it remains difficult to predict the antigens that will be …
control tumor growth. However, it remains difficult to predict the antigens that will be …
A large peptidome dataset improves HLA class I epitope prediction across most of the human population
Prediction of HLA epitopes is important for the development of cancer immunotherapies and
vaccines. However, current prediction algorithms have limited predictive power, in part …
vaccines. However, current prediction algorithms have limited predictive power, in part …
Mapping the tumour human leukocyte antigen (HLA) ligandome by mass spectrometry
LK Freudenmann, A Marcu, S Stevanović - Immunology, 2018 - Wiley Online Library
The entirety of human leukocyte antigen (HLA)‐presented peptides is referred to as the HLA
ligandome of a cell or tissue, in tumours often termed immunopeptidome. Mapping the …
ligandome of a cell or tissue, in tumours often termed immunopeptidome. Mapping the …
[HTML][HTML] Mass spectrometry based immunopeptidomics leads to robust predictions of phosphorylated HLA class I ligands
M Solleder, P Guillaume, J Racle, J Michaux… - Molecular & Cellular …, 2020 - ASBMB
The presentation of peptides on class I human leukocyte antigen (HLA-I) molecules plays a
central role in immune recognition of infected or malignant cells. In cancer, non-self HLA-I …
central role in immune recognition of infected or malignant cells. In cancer, non-self HLA-I …
[HTML][HTML] Predicting antigen presentation—what could we learn from a million peptides?
D Gfeller, M Bassani-Sternberg - Frontiers in immunology, 2018 - frontiersin.org
Antigen presentation lies at the heart of immune recognition of infected or malignant cells.
For this reason, important efforts have been made to predict which peptides are more likely …
For this reason, important efforts have been made to predict which peptides are more likely …
[HTML][HTML] HLA Ligand Atlas: a benign reference of HLA-presented peptides to improve T-cell-based cancer immunotherapy
Background The human leucocyte antigen (HLA) complex controls adaptive immunity by
presenting defined fractions of the intracellular and extracellular protein content to immune …
presenting defined fractions of the intracellular and extracellular protein content to immune …
[HTML][HTML] Predicting HLA class II antigen presentation through integrated deep learning
Accurate prediction of antigen presentation by human leukocyte antigen (HLA) class II
molecules would be valuable for vaccine development and cancer immunotherapies …
molecules would be valuable for vaccine development and cancer immunotherapies …
Robust prediction of HLA class II epitopes by deep motif deconvolution of immunopeptidomes
J Racle, J Michaux, GA Rockinger, M Arnaud… - Nature …, 2019 - nature.com
Predictions of epitopes presented by class II human leukocyte antigen molecules (HLA-II)
have limited accuracy, restricting vaccine and therapy design. Here we combined unbiased …
have limited accuracy, restricting vaccine and therapy design. Here we combined unbiased …
[HTML][HTML] Mass spectrometry profiling of HLA-associated peptidomes in mono-allelic cells enables more accurate epitope prediction
Identification of human leukocyte antigen (HLA)-bound peptides by liquid chromatography-
tandem mass spectrometry (LC-MS/MS) is poised to provide a deep understanding of rules …
tandem mass spectrometry (LC-MS/MS) is poised to provide a deep understanding of rules …
[HTML][HTML] Machine learning predictions of MHC-II specificities reveal alternative binding mode of class II epitopes
J Racle, P Guillaume, J Schmidt, J Michaux, A Larabi… - Immunity, 2023 - cell.com
CD4+ T cells orchestrate the adaptive immune response against pathogens and cancer by
recognizing epitopes presented on class II major histocompatibility complex (MHC-II) …
recognizing epitopes presented on class II major histocompatibility complex (MHC-II) …