Cdc42 GTPase plays a critical role in the establishment of cell polarity in most eukaryotic
organisms. Cdc42 active state, as that of other GTPases, depends on the bound nucleotide …

Cdc42 GTPase is required for polarization in eukaryotic cells, but its spatial regulation is
poorly understood. In Schizosaccharomyces pombe, Cdc42p is activated by Scd1p and …

The Rho-family GTPase Cdc42 regulates cell polarity and localizes to the cell division site.
Cdc42 is activated by guanine nucleotide exchange factors (GEFs). We report that Cdc42 …

Abstract Cdc42, a Rho-family GTPase, is a master regulator of cell polarity. Recently, it has
been shown that Cdc42 also facilitates proper cytokinesis in the fission yeast …

Rho GTPases control polarized cell growth and are well-known regulators of exocytic and
endocytic processes. Cdc42 is an essential GTPase, conserved from yeast to humans, that …

A key question in cytokinesis is how the plane of cell division is positioned within the cell.
Although a number of cytokinesis factors involved in formation of the actomyosin contractile …

Cytokinesis in mammalian cells requires actin assembly at the equatorial region. Although
functions of RhoA in this process have been well established, additional mechanisms are …

In budding yeast, the release of the protein phosphatase Cdc14 from its inhibitor Cfi1/Net1 in
the nucleolus during anaphase triggers the inactivation of Clb CDKs that leads to exit from …

ABSTRACT The conserved Rho-family GTPase Cdc42 plays a central role in eukaryotic cell
polarity. The rod-shaped fission yeast Schizosaccharomyces pombe has two Cdc42 …

Active Cdc42 GTPase, a key regulator of cell polarity, displays oscillatory dynamics that are
anticorrelated at the two cell tips in fission yeast. Anticorrelation suggests competition for …