Computational Selection of RNA Aptamer against Angiopoietin‐2 and Experimental Evaluation
Angiogenesis plays a decisive role in the growth and spread of cancer and angiopoietin‐2
(Ang2) is in the spotlight of studies for its unique role in modulating angiogenesis. The aim of …
(Ang2) is in the spotlight of studies for its unique role in modulating angiogenesis. The aim of …
Computational approach to analyze isolated ssDNA aptamers against angiotensin II
Aptamers are oligonucleotides with highly structured molecules that can bind to their targets
through specific 3-D conformation. Commonly, not all the nucleotides such as primer binding …
through specific 3-D conformation. Commonly, not all the nucleotides such as primer binding …
In silico designed RNA aptamer against epithelial cell adhesion molecule for cancer cell imaging
R Bavi, Z Liu, Z Han, H Zhang, Y Gu - Biochemical and biophysical …, 2019 - Elsevier
Aptamers are short, single-stranded oligonucleotides that bind to their targets with high
affinity and specificity. Usually, aptamers are selected experimentally using SELEX …
affinity and specificity. Usually, aptamers are selected experimentally using SELEX …
In silico design of novel aptamers utilizing a hybrid method of machine learning and genetic algorithm
Aptamers can be regarded as efficient substitutes for monoclonal antibodies in many
diagnostic and therapeutic applications. Due to the tedious and prohibitive nature of SELEX …
diagnostic and therapeutic applications. Due to the tedious and prohibitive nature of SELEX …
Revealing the molecular interactions of aptamers that specifically bind to the extracellular domain of HER2 cancer biomarker protein: An in silico assessment
Single-stranded (ss) oligonucleotide aptamers are emerging as the promising substitutes for
monoclonal antibodies because of their low production cost and good batch-to-batch …
monoclonal antibodies because of their low production cost and good batch-to-batch …
A validation strategy for in silico generated aptamers
R Cataldo, F Ciriaco, E Alfinito - Computational biology and chemistry, 2018 - Elsevier
The selection of high-affinity aptamers is of paramount interest for clinical and technological
applications. A novel strategy is proposed to validate the reliability of the 3D structures of a …
applications. A novel strategy is proposed to validate the reliability of the 3D structures of a …
In silico approach for Post-SELEX DNA aptamers: A mini-review
Aptamers are short oligonucleotides that possess high specificity and affinity against their
target. Generated via Systematic Evolution of Ligands by Exponential Enrichment,(SELEX) …
target. Generated via Systematic Evolution of Ligands by Exponential Enrichment,(SELEX) …
[HTML][HTML] Design and prediction of aptamers assisted by in silico methods
SJ Lee, J Cho, BH Lee, D Hwang, JW Park - Biomedicines, 2023 - mdpi.com
An aptamer is a single-stranded DNA or RNA that binds to a specific target with high binding
affinity. Aptamers are developed through the process of systematic evolution of ligands by …
affinity. Aptamers are developed through the process of systematic evolution of ligands by …
Improvement of the VEGF binding ability of DNA aptamers through in silico maturation and multimerization strategy
T Fukaya, K Abe, N Savory, K Tsukakoshi… - Journal of …, 2015 - Elsevier
Aptamers are mainly selected by in vitro selection using random nucleic acid libraries.
These aptamers have often shown insufficient affinity for biomedical applications. We …
These aptamers have often shown insufficient affinity for biomedical applications. We …
[HTML][HTML] Binding and structural properties of DNA aptamers with VEGF-A-mimic activity
T Yoshitomi, M Hayashi, T Oguro, K Kimura… - … Therapy-Nucleic Acids, 2020 - cell.com
Vascular endothelial growth factors (VEGFs) are hypoxia-inducible secreted proteins to
promote angiogenesis, in which VEGF-A is an important molecule that binds and activates …
promote angiogenesis, in which VEGF-A is an important molecule that binds and activates …