The extensive oxygen gradient between the air we breathe (Po2~ 21 kPa) and its ultimate
distribution within mitochondria (as low as~ 0.5–1 kPa) is testament to the efforts expended …

Hypoxia is characterized as insufficient oxygen delivery to tissues and cells in the body and
is prevalent in many human physiology processes and diseases. Thus, it is an attractive …

Most conventional incubators used in cell culture do not regulate O2 levels, making the
headspace O2 concentration~ 18%. In contrast, most human tissues are exposed to 2–6 …

Regenerative medicine relies on harnessing the capacity of stem cells to grow, divide and
differentiate safely and predictably. This may be in the context of expanding stem cells in …

Although O2 concentrations are considerably lowered in vivo, depending on the tissue and
cell population in question (some cells need almost anoxic environment for their …

Most mammalian tissue cells experience oxygen partial pressures in vivo equivalent to 1–
6% O2 (ie, physioxia). In standard cell culture, however, headspace O2 levels are usually …

When oxygen supply to tissues is limiting, mitochondrial respiration and ATP production are
compromised. To assess the bioenergetic consequences under normoxia and hypoxia …

Introduction‐Imaging of hypoxic areas‐Hypoxia markers‐Positron emission tomography
(PET)‐Near‐infrared spectroscopy (NIRS)‐Magnetic resonance spectroscopy (MRS) …

Molecular oxygen is one of the most important variables in modern cell culture systems.
Fluctuations in its concentration can affect cell growth, differentiation, signaling, and free …

Molecular oxygen (O2) sustains intracellular bioenergetics and is consumed by numerous
biochemical reactions, making it essential for most species on Earth. Accordingly, decreased …