Ergot alkaloids: synthetic approaches to lysergic acid and clavine alkaloids

H Liu, Y Jia - Natural product reports, 2017 - pubs.rsc.org
Covering: 2000 to 2017 Ergot alkaloids are among the most important pharmaceuticals and
natural toxins. Significant progress has been achieved in recent years on the research of …

Biosynthesis, total synthesis, and biological profiles of Ergot alkaloids

NR Tasker, P Wipf - The Alkaloids: Chemistry and Biology, 2021 - Elsevier
While the use of ergot alkaloids in folk medicine has been practiced for millennia, systematic
investigations on their therapeutic potential began about 100 years ago. Subsequently …

Historical view on ergot alkaloids

A Hofmann - Pharmacology, 1978 - karger.com
A short survey of the history of ergot, of the original and, for a long time, only source of ergot
alkaloids, is given. Once a dreaded poison, ergot has changed its role over the centuries to …

Biosynthetic pathways of ergot alkaloids

N Gerhards, L Neubauer, P Tudzynski, SM Li - Toxins, 2014 - mdpi.com
Ergot alkaloids are nitrogen-containing natural products belonging to indole alkaloids. The
best known producers are fungi of the phylum Ascomycota, eg, Claviceps, Epichloë …

Biosynthesis of the ergot alkaloids

D Jakubczyk, JZ Cheng, SE O'Connor - Natural product reports, 2014 - pubs.rsc.org
Covering: 2011 to early 2014 The ergots are a structurally diverse group of alkaloids derived
from tryptophan 7 and dimethylallyl pyrophosphate (DMAPP) 8. The potent bioactivity of …

Ergot alkaloids: structure diversity, biosynthetic gene clusters and functional proof of biosynthetic genes

C Wallwey, SM Li - Natural product reports, 2011 - pubs.rsc.org
Covering: 2000 to 2010 Ergot alkaloids are toxins and important pharmaceuticals which are
produced biotechnologically on an industrial scale. They have been identified in two orders …

[HTML][HTML] Methods of lysergic acid synthesis—the key ergot alkaloid

MK Jastrzębski, AA Kaczor, TM Wróbel - Molecules, 2022 - mdpi.com
Ergot is the spore form of the fungus Claviceps purpurea. Ergot alkaloids are indole
compounds that are biosynthetically derived from L-tryptophan and represent the largest …

Recent progress in ergot alkaloid research

JJ Chen, MY Han, T Gong, JL Yang, P Zhu - RSC advances, 2017 - pubs.rsc.org
Ergot alkaloids are a class of indole derivatives produced by the genera of Ascomycota
including Claviceps, Aspergillus, Penicillium, and Epichloë. Many natural and semi-synthetic …

Biochemistry of ergot alkaloids—achievements and challenges

D Gröcer, HG Floss - The alkaloids: chemistry and biology, 1998 - Elsevier
Publisher Summary The chapter discusses the biochemistry of ergot alkaloids, its
achievements, and challenges and gives a clear picture of the current knowledge of the …

Biosynthesis of ergot alkaloids and related compounds

HG Floss - Tetrahedron, 1976 - Elsevier
Ergot alkaloids, the metabolic products of various species of the parasitic fungus CIauiceps(
Clavicipitales), have many fascinating features which may account for the long-standing …