The high selectivity of the human blood-brain barrier (BBB) restricts delivery of many
pharmaceuticals and therapeutic antibodies to the central nervous system. Here, we …

The blood–brain barrier (BBB) greatly restricts the entry of biological and engineered
therapeutic molecules into the brain. Due to challenges in translating results from animal …

The blood-brain barrier (BBB) is composed of brain microvascular endothelial cells (BMECs)
that regulate brain homeostasis, and astrocytes within the brain are involved in the …

The blood-brain barrier (BBB) tightly regulates the entry of solutes from blood into the brain
and is disrupted in several neurological diseases. Using Organ-Chip technology, we created …

Efficient delivery of therapeutics across the neuroprotective blood–brain barrier (BBB)
remains a formidable challenge for central nervous system drug development. High‐fidelity …

Background Receptor-mediated transcytosis is one of the major routes for drug delivery of
large molecules into the brain. The aim of this study was to develop a novel model of the …

Background The pathways that control protein transport across the blood–brain barrier
(BBB) remain poorly characterized. Despite great advances in recapitulating the human BBB …

Culture-based blood–brain barrier (BBB) models are crucial tools to enable rapid screening
of brain-penetrating drugs. However, reproducibility of in vitro barrier properties and …

Here, we have developed and evaluated a microfluidic-based human blood–brain-barrier
(μBBB) platform that models and predicts brain tissue uptake of small molecule drugs and …

The blood-brain barrier (BBB) is crucial to the health of the brain and is often compromised
in neurological disease. Moreover, because of its barrier properties, this endothelial …