Mitochondrial transfer via tunneling nanotubes is an important mechanism by which mesenchymal stem cells enhance macrophage phagocytosis in the in vitro and in …

MV Jackson, TJ Morrison, DF Doherty, DF McAuley… - Stem …, 2016 - academic.oup.com
Mesenchymal stromal cells (MSC) have been reported to improve bacterial clearance in
preclinical models of Acute Respiratory Distress Syndrome (ARDS) and sepsis. The …

Analysis of mitochondrial transfer in direct co-cultures of human monocyte-derived macrophages (MDM) and mesenchymal stem cells (MSC)

MV Jackson, AD Krasnodembskaya - Bio-protocol, 2017 - bio-protocol.org
Mesenchymal stem/stromal cells (MSC) are adult stem cells which have been shown to
improve survival, enhance bacterial clearance and alleviate inflammation in pre-clinical …

Mesenchymal stromal cells modulate macrophages in clinically relevant lung injury models by extracellular vesicle mitochondrial transfer

TJ Morrison, MV Jackson, EK Cunningham… - American journal of …, 2017 - atsjournals.org
Rationale: Acute respiratory distress syndrome (ARDS) remains a major cause of respiratory
failure in critically ill patients. Mesenchymal stromal cells (MSCs) are a promising candidate …

Mesenchymal stem cells enhance NOX2-dependent reactive oxygen species production and bacterial killing in macrophages during sepsis

R Rabani, A Volchuk, M Jerkic… - European …, 2018 - Eur Respiratory Soc
Human mesenchymal stem/stromal cells (MSCs) have been reported to produce an M2-like,
alternatively activated phenotype in macrophages. In addition, MSCs mediate effective …

Bone marrow‑derived mesenchymal stem cells rescue injured H9c2 cells via transferring intact mitochondria through tunneling nanotubes in an in vitro simulated …

H Han, J Hu, Q Yan, J Zhu, Z Zhu… - Molecular …, 2016 - spandidos-publications.com
The transplantation of mesenchymal stem cells (MSCs) is considered to be a promising
treatment for ischemic heart disease; however, the therapeutic effects and underlying …

Therapeutic Effects of Human Mesenchymal Stem Cells in Ex Vivo Human Lungs Injured with Live Bacteria

JW Lee, A Krasnodembskaya… - American journal of …, 2013 - atsjournals.org
Rationale: Mesenchymal stem cells secrete paracrine factors that can regulate lung
permeability and decrease inflammation, making it a potentially attractive therapy for acute …

Mitochondrial transfer from bone-marrow–derived stromal cells to pulmonary alveoli protects against acute lung injury

MN Islam, SR Das, MT Emin, M Wei, L Sun… - Nature medicine, 2012 - nature.com
Bone marrow–derived stromal cells (BMSCs) protect against acute lung injury (ALI). To
determine the role of BMSC mitochondria in this protection, we airway-instilled mice first with …

[PDF][PDF] Connexin 43-mediated mitochondrial transfer of iPSC-MSCs alleviates asthma inflammation

Y Yao, XL Fan, D Jiang, Y Zhang, X Li, ZB Xu, SB Fang… - Stem cell reports, 2018 - cell.com
We previously identified an immunomodulatory role of human induced pluripotent stem cell
(iPSC)-derived mesenchymal stem cells (MSCs) in asthmatic inflammation. Mitochondrial …

Human bone marrow mesenchymal stem cells rescue endothelial cells experiencing chemotherapy stress by mitochondrial transfer via tunneling nanotubes

Y Feng, R Zhu, J Shen, JM Wu, W Lu… - Stem Cells and …, 2019 - liebertpub.com
Tunneling nanotubes (TNTs) are newly discovered tubular structures between two distant
cells that facilitate the intercellular exchange of signals and components. Recent reports …

Mesenchymal stem cells enhance survival and bacterial clearance in murine Escherichia coli pneumonia

N Gupta, A Krasnodembskaya, M Kapetanaki… - Thorax, 2012 - thorax.bmj.com
Rationale Bacterial pneumonia is the most common infectious cause of death worldwide
and treatment is increasingly hampered by antibiotic resistance. Mesenchymal stem cells …