The range of applications for aptamers, small oligonucleotide-based receptors binding to
their targets with high specificity and affinity, has been steadily expanding. Our …

Aptamers are oligonucleotide receptors obtained through an iterative selection process from
random-sequence libraries. Though many aptamers for a broad range of targets with high …

Molecular recognition of small molecule ligands by the nucleic acid aptamers for tobramycin,
ATP, and FMN has been examined using electrospray ionization mass spectrometry (ESI …

Understanding how aptamer structure and function are related is crucial in the design and
development of aptamer-based biosensors. We have analyzed a series of cocaine-binding …

We reported over 20 years ago MNS-4.1, the first DNA aptamer with a micromolar affinity for
cocaine. MNS-4.1 is based on a structural motif that is very common in any random pool of …

The cocaine-binding aptamer is unusual in that it tightly binds molecules other than the
ligand it was selected for. Here, we study the interaction of the cocaine-binding aptamer with …

In this manuscript, we compare different analytical methodologies to validate or disprove the
binding capabilities of aptamer sequences. This was prompted by the lack of a universally …

Nucleic-acid aptamers are bio-molecular recognition agents that bind to their targets with
high specificity and affinity and hold promise in a range of biosensor and therapeutic …

Aptamers are widely used in small molecule detection applications due to their specificity,
stability, and cost effectiveness. One key challenge in utilizing aptamers in sensors is …

We have used a combined approach of NMR spectroscopy and isothermal titration
calorimetry (ITC) to determine the ligand-binding mechanism employed by a cocaine …