Colorectal mucosa is targeted by toxic agents, which can initiate or promote colon cancer.
The mechanism of damage might be a focal irritation with loss of normal epithelial cell …

Background Colorectal cancer (CRC) infiltration by adaptive immune system cells correlates
with favorable prognosis. The role of the innate immune system is still debated. Here we …

Chronic mucosal inflammation is considered a risk factor for colorectal cancer. Neutrophils
are a major source of oxidants, whereas cyclooxygenase 2 (COX-2) and Hypoxia Inducible …

Background Patients with extensive, longstanding ulcerative colitis (UC), a disease of
chronic colonic inflammation, are at risk for colorectal cancer (CRC). Elucidating the …

Colorectal cancer (CRC) infiltration by cells expressing myeloperoxidase (MPO) or CD8
positive T lymphocytes has been shown to be independently associated with favorable …

Patients with ulcerative colitis and Crohn's disease are at increased risk for developing
colorectal cancer (CRC). Chronic inflammation is believed to promote carcinogenesis. The …

Ulcerative colitis (UC) is characterized by repeated flare-ups of inflammation that can lead to
oncogenic insults to the colonic epithelial. UC-associated carcinogenesis presents a …

One of the most serious complications of ulcerative colitis is the development of colorectal
cancer. Screening patients with ulcerative colitis by standard histological examination of …

Background Myeloperoxidase (MPO) has been demonstrated to be a local mediator of
inflammation in tissue damage in various inflammatory diseases. Given its controversial …

High macrophage infiltration has been correlated to improved survival in colorectal cancer
(CRC). Tumor associated macrophages (TAMs) play complex roles in tumorigenesis since …