Psoriasis is a chronic inflammatory skin disease associated with a T helper 17 response.
Yet, it has proved challenging to identify relevant peptide-based T cell antigens. Antigen …

A large proportion of human T cells are autoreactive to group 1 CD1 proteins, which include
CD1a, CD1b, and CD1c. However, the physiological role of the CD1 proteins remains poorly …

Atopic dermatitis is a common pruritic skin disease in which barrier dysfunction and
cutaneous inflammation contribute to pathogenesis. Mechanisms underlying the associated …

Resolution of inflammation is an active process that is mediated in part by antiinflammatory
lipid mediators. Although phospholipase A2 (PLA2) enzymes have been implicated in the …

Lipid mediators, such as prostanoids and leukotrienes (LTs), exert a range of actions
through their own receptors on cell surfaces in various pathophysiological conditions. It has …

Psoriasis is a chronic inflammatory skin disorder that affects~ 2%–3% of the worldwide
population. Inappropriate and excessive activation of endosomal Toll‐like receptors 7, 8 …

Psoriasis is a common immune‐mediated disease that affects 2%‐4% of individuals in North
America and Europe. In the past decade, advances in research have led to an improved …

The CD18 hypomorphic (CD18hypo) PL/J mouse model clinically resembling human
psoriasis is characterized by reduced expression of the common chain of β2 integrins …

Several subtypes of APC s are found in psoriasis patients, but their involvement in disease
pathogenesis is poorly understood. Here, we investigated the contribution of Langerhans …

Psoriasis is an immune-mediated inflammatory disease of the skin. Previous studies
including ours have shown that IL-17A plays a major role in its pathogenesis; however, its …