Seasonal influenza vaccines offer little protection against pandemic influenza virus strains. It
is difficult to create effective prepandemic vaccines because it is uncertain which influenza …

Influenza viruses are respiratory pathogens of public health concern worldwide with up to
650,000 deaths occurring each year. Seasonal influenza virus vaccines are employed to …

Combined vaccine formulations targeting not only hemagglutinin but also other influenza
virus antigens could form the basis for a universal influenza virus vaccine that has the …

Licensed seasonal influenza vaccination results in variable effectiveness, and the
substantial residual medical need calls for novel vaccines to induce better and broader …

Messenger RNA (mRNA) vaccines represent a new, effective vaccine platform with high
capacity for rapid development. Generation of a universal influenza virus vaccine with the …

Recent approval of mRNA vaccines for emergency use against COVID-19 is likely to
promote rapid development of mRNA-based vaccines targeting a wide range of infectious …

Currently available influenza virus vaccines have inadequate effectiveness and are
reformulated annually due to viral antigenic drift. Thus, development of a vaccine that …

Recently, the World Health Organization confirmed 120 new human cases of avian H7N9
influenza in China resulting in 37 deaths, highlighting the concern for a potential pandemic …

Universal influenza vaccines should protect against continuously evolving and newly
emerging influenza viruses. T cells may be an essential target of such vaccines, as they can …

The rapid dissemination of the 2009 pandemic influenza virus underscores the need for
universal influenza vaccines that elicit protective immunity to diverse viral strains. Here, we …